Overactive Bladder in the Vulnerable Elderly
Overview
Affiliations
Overactive bladder (OAB) is a common problem that may occur in individuals of all ages. It has a considerable impact on patient quality of life, and although moderately effective management strategies do exist, this condition often remains undiagnosed and untreated. OAB needs to be viewed as a symptom complex. Its presentation and management are complicated in the vulnerable elderly by the presence of baseline frailty and multiple coexisting chronic conditions. Furthermore, and beyond a simple understanding of symptomatology, providers must address patient goals and motivations as well as the expectations of caretakers. These multiple levels of perception, function, expectations, and treatment efficacy/risks must be tailored to the individual patient. While the vulnerable elderly patient may often have evidence of urinary tract dysfunction, OAB and urge urinary incontinence in this population must be understood as a multifactorial geriatric syndrome and viewed in the context of medical and functional baseline and precipitating risk factors. Expectations and goals must be tailored to the resources of vulnerable elderly patients and their caregivers, and care must be coordinated with other medical care providers. The management of OAB in the vulnerable elderly often poses significant management challenges. Nonetheless, with a thoughtful approach and an aim towards future research specifically for this population, significant reductions in morbidity and mortality long with enhancement in health-related quality of life are possible.
Polychlorinated biphenyl (PCB) exposure in adult female mice can influence bladder contractility.
Lavery T, Spiegelhoff A, Wang K, Kennedy C, Ridlon M, Keil Stietz K Am J Clin Exp Urol. 2023; 11(5):367-384.
PMID: 37941647 PMC: 10628623.
Khizer Z, Akram M, Tahir M, Liu W, Lou S, Conway B Pharmaceuticals (Basel). 2023; 16(3).
PMID: 36986471 PMC: 10056888. DOI: 10.3390/ph16030372.
Safety and Tolerability of Fesoterodine in Older Adult Patients with Overactive Bladder.
Heesakkers J, Te Dorsthorst M, Wagg A Can Geriatr J. 2022; 25(1):72-78.
PMID: 35310472 PMC: 8887709. DOI: 10.5770/cgj.25.530.
Yoshida M, Satake S, Ishida K, Tanaka Y, Ukai M BMC Geriatr. 2022; 22(1):68.
PMID: 35062875 PMC: 8783467. DOI: 10.1186/s12877-022-02756-7.
Amiri M, Schneider T, Oelke M, Murgas S, Michel M J Clin Med. 2021; 10(2).
PMID: 33467690 PMC: 7830207. DOI: 10.3390/jcm10020311.