Inflammasomes

Overview

Journal Cold Spring Harb Perspect Biol

Specialties Biology
Molecular Biology

Date 2014 Oct 18

PMID 25324215

Citations 183

Authors

Marcel R de Zoete

Noah W Palm

Shu Zhu

Richard A Flavell

Affiliations

Soon will be listed here.

Abstract

Inflammasomes are large cytosolic multiprotein complexes that assemble in response to detection of infection- or stress-associated stimuli and lead to the activation of caspase-1-mediated inflammatory responses, including cleavage and unconventional secretion of the leaderless proinflammatory cytokines IL-1β and IL-18, and initiation of an inflammatory form of cell death referred to as pyroptosis. Inflammasome activation can be induced by a wide variety of microbial pathogens and generally mediates host defense through activation of rapid inflammatory responses and restriction of pathogen replication. In addition to its role in defense against pathogens, recent studies have suggested that the inflammasome is also a critical regulator of the commensal microbiota in the intestine. Finally, inflammasomes have been widely implicated in the development and progression of various chronic diseases, such as gout, atherosclerosis, and metabolic syndrome. In this perspective, we discuss the role of inflammasomes in infectious and noninfectious inflammation and highlight areas of interest for future studies of inflammasomes in host defense and chronic disease.

Citing Articles

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PMID: 40002829 PMC: 11852453. DOI: 10.3390/biomedicines13020416.

Activation of the conserved Hippo kinases by inflammasome-triggered proteolytic cleavage controls programmed cell death in macrophages.

Su Y, Quagliato S, St Louis B, Abdelaziz M, He Y, Bondage D Proc Natl Acad Sci U S A. 2025; 122(5):e2418613122.

PMID: 39883842 PMC: 11804562. DOI: 10.1073/pnas.2418613122.

Comparison of Methods of Detecting IL-1β in the Blood of Alzheimer's Disease Subjects.

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Aerosol Inhalation of Luteolin-7-O-Glucuronide Exerts Anti-Inflammatory Effects by Inhibiting NLRP3 Inflammasome Activation.

Li J, Song L, Li H, Gao Y, Chen T, Zhang Z Pharmaceuticals (Basel). 2025; 17(12.

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