A Shared Genetic Propensity Underlies Experiences of Bullying Victimization in Late Childhood and Self-rated Paranoid Thinking in Adolescence

Overview

Journal Schizophr Bull

Publisher Oxford University Press

Specialty Psychiatry

Date 2014 Oct 18

PMID 25323579

Citations 28

Authors

Sania Shakoor

Phillip McGuire

Alastair G Cardno

Daniel Freeman

Robert Plomin

Angelica Ronald

Affiliations

Soon will be listed here.

Abstract

Background: Bullying is a risk factor for developing psychotic experiences (PEs). Whether bullying is associated with particular PEs, and the extent to which genes and environments influence the association, are unknown. This study investigated which specific PEs in adolescence are associated with earlier bullying victimization and the genetic and environmental contributions underlying their association.

Method: Participants were 4826 twin pairs from a longitudinal community-based twin study in England and Wales who reported on their bullying victimization at the age of 12 years. Measures of specific PEs (self-rated Paranoia, Hallucinations, Cognitive disorganization, Grandiosity, Anhedonia, and parent-rated Negative Symptoms) were recorded at age of 16 years.

Results: Childhood bullying victimization was most strongly associated with Paranoia in adolescence (r = .26; P < .01), with weaker associations with Hallucinations, Cognitive Disorganization, parent-rated Negative Symptoms (r = .12-.20; P < .01), Grandiosity (r = .04; P < .05), and Anhedonia (r = .00, n.s.). Bivariate twin model-fitting demonstrated that bullying victimization and Paranoia were both heritable (35% and 52%, respectively) with unique environmental influences (39% and 48%, respectively), and bullying victimization showed common environmental influences (26%). The association between bullying victimization and Paranoia operated almost entirely via genetic influences (bivariate heritability = 93%), with considerable genetic overlap (genetic correlation = .55).

Conclusion: In contrast to the assumed role of bullying victimization as an environmental trigger, these data suggest that bullying victimization in late childhood is particularly linked to self-rated Paranoia in adolescence via a shared genetic propensity. Clinically, individuals with a history of bullying victimization are predicted to be particularly susceptible to paranoid symptoms.

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References

Varese F, Smeets F, Drukker M, Lieverse R, Lataster T, Viechtbauer W . Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective- and cross-sectional cohort studies. Schizophr Bull. 2012; 38(4):661-71. PMC: 3406538. DOI: 10.1093/schbul/sbs050. View

Zammit S, Owen M, Evans J, Heron J, Lewis G . Cannabis, COMT and psychotic experiences. Br J Psychiatry. 2011; 199(5):380-5. DOI: 10.1192/bjp.bp.111.091421. View

Boker S, Neale M, Maes H, Wilde M, Spiegel M, Brick T . OpenMx: An Open Source Extended Structural Equation Modeling Framework. Psychometrika. 2012; 76(2):306-317. PMC: 3525063. DOI: 10.1007/s11336-010-9200-6. View

Mullins-Sweatt S, Jamerson J, Samuel D, Olson D, Widiger T . Psychometric properties of an abbreviated instrument of the five-factor model. Assessment. 2006; 13(2):119-37. DOI: 10.1177/1073191106286748. View

Bebbington P, Jonas S, Kuipers E, King M, Cooper C, Brugha T . Childhood sexual abuse and psychosis: data from a cross-sectional national psychiatric survey in England. Br J Psychiatry. 2011; 199(1):29-37. DOI: 10.1192/bjp.bp.110.083642. View

Sullivan S, Bentall R, Fernyhough C, Pearson R, Zammit S . Cognitive styles and psychotic experiences in a community sample. PLoS One. 2013; 8(11):e80055. PMC: 3828222. DOI: 10.1371/journal.pone.0080055. View

Kelleher I, Connor D, Clarke M, Devlin N, Harley M, Cannon M . Prevalence of psychotic symptoms in childhood and adolescence: a systematic review and meta-analysis of population-based studies. Psychol Med. 2012; 42(9):1857-63. DOI: 10.1017/S0033291711002960. View

Mezulis A, Hyde J, Abramson L . The developmental origins of cognitive vulnerability to depression: temperament, parenting, and negative life events in childhood as contributors to negative cognitive style. Dev Psychol. 2006; 42(6):1012-25. DOI: 10.1037/0012-1649.42.6.1012. View

Ball H, Arseneault L, Taylor A, Maughan B, Caspi A, Moffitt T . Genetic and environmental influences on victims, bullies and bully-victims in childhood. J Child Psychol Psychiatry. 2008; 49(1):104-12. DOI: 10.1111/j.1469-7610.2007.01821.x. View

10.

Arseneault L, Bowes L, Shakoor S . Bullying victimization in youths and mental health problems: 'much ado about nothing'?. Psychol Med. 2009; 40(5):717-29. DOI: 10.1017/S0033291709991383. View

11.

Arseneault L, Cannon M, Fisher H, Polanczyk G, Moffitt T, Caspi A . Childhood trauma and children's emerging psychotic symptoms: A genetically sensitive longitudinal cohort study. Am J Psychiatry. 2010; 168(1):65-72. PMC: 3536053. DOI: 10.1176/appi.ajp.2010.10040567. View

12.

Haworth C, Davis O, Plomin R . Twins Early Development Study (TEDS): a genetically sensitive investigation of cognitive and behavioral development from childhood to young adulthood. Twin Res Hum Genet. 2012; 16(1):117-25. PMC: 3817931. DOI: 10.1017/thg.2012.91. View

13.

Wigman J, Vollebergh W, Raaijmakers Q, Iedema J, van Dorsselaer S, Ormel J . The structure of the extended psychosis phenotype in early adolescence--a cross-sample replication. Schizophr Bull. 2010; 37(4):850-60. PMC: 3122288. DOI: 10.1093/schbul/sbp154. View

14.

Saudino K . Behavioral genetics and child temperament. J Dev Behav Pediatr. 2005; 26(3):214-23. PMC: 1188235. DOI: 10.1097/00004703-200506000-00010. View

15.

Freeman D, Stahl D, McManus S, Meltzer H, Brugha T, Wiles N . Insomnia, worry, anxiety and depression as predictors of the occurrence and persistence of paranoid thinking. Soc Psychiatry Psychiatr Epidemiol. 2011; 47(8):1195-203. DOI: 10.1007/s00127-011-0433-1. View

16.

Hur Y, Cherny S, Sham P . Heritability of hallucinations in adolescent twins. Psychiatry Res. 2012; 199(2):98-101. DOI: 10.1016/j.psychres.2012.04.024. View

17.

Kelleher I, Harley M, Lynch F, Arseneault L, Fitzpatrick C, Cannon M . Associations between childhood trauma, bullying and psychotic symptoms among a school-based adolescent sample. Br J Psychiatry. 2008; 193(5):378-82. DOI: 10.1192/bjp.bp.108.049536. View

18.

Oliver B, Trzaskowski M, Plomin R . Genetics of parenting: The power of the dark side. Dev Psychol. 2013; 50(4):1233-40. PMC: 3977675. DOI: 10.1037/a0035388. View

19.

Craig W, Harel-Fisch Y, Fogel-Grinvald H, Dostaler S, Hetland J, Simons-Morton B . A cross-national profile of bullying and victimization among adolescents in 40 countries. Int J Public Health. 2009; 54 Suppl 2:216-24. PMC: 2747624. DOI: 10.1007/s00038-009-5413-9. View

20.

Polanczyk G, Moffitt T, Arseneault L, Cannon M, Ambler A, Keefe R . Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort. Arch Gen Psychiatry. 2010; 67(4):328-38. PMC: 3776482. DOI: 10.1001/archgenpsychiatry.2010.14. View