Epstein-Barr Virus Infection Mechanisms

Overview

Journal Chin J Cancer

Publisher Biomed Central

Specialty Oncology

Date 2014 Oct 18

PMID 25322867

Citations 11

Authors

Liudmila S Chesnokova

Lindsey M Hutt-Fletcher

Affiliations

Soon will be listed here.

Abstract

Epstein-Barr virus (EBV) infection occurs by distinct mechanisms across different cell types. EBV infection of B cells in vitro minimally requires 5 viral glycoproteins and 2 cellular proteins. By contrast, infection of epithelial cells requires a minimum of 3 viral glycoproteins, which are capable of interacting with one or more of 3 different cellular proteins. The full complement of proteins involved in entry into all cell types capable of being infected in vivo is unknown. This review discusses the events that occur when the virus is delivered into the cytoplasm of a cell, the players known to be involved in these events, and the ways in which these players are thought to function.

Citing Articles

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