Clinical Significance of Molecular Diagnosis for Gastric Cancer Lymph Node Micrometastasis

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2014 Oct 17

PMID 25320510

Citations 6

Authors

Hiromichi Sonoda

Tohru Tani

Affiliations

Soon will be listed here.

Abstract

Advances in molecular diagnostic tools have allowed the identification of lymph node micrometastasis (LNM), including isolated tumor cells, in cancer patients. While immunohistochemistry and reverse transcription-polymerase chain reaction have been used to identify LNM in patients with gastric cancer, the clinical significance of this finding remains unclear. Recently, minimally invasive treatments, such as endoscopic submucosal dissection and laparoscopic surgery, are widely performed to help improve postsurgical quality of life (QOL). However, it is important to maintain the balance between QOL and curability when making treatments decision for patients with gastric cancer. If minimally invasive surgery based on accurate intraoperative LNM diagnosis was established, it could be performed safely. Therefore, we reviewed the clinical significance of LNM detected by molecular techniques as an important target for treatment decision making with gastric cancer patients.

Citing Articles

Lymph Node Involvement in Advanced Gastric Cancer in the Era of Multimodal Treatment-Oncological and Surgical Perspective.

Pelc Z, Skorzewska M, Rawicz-Pruszynski K, Polkowski W Cancers (Basel). 2021; 13(10).

PMID: 34065596 PMC: 8160868. DOI: 10.3390/cancers13102509.

Clinical Significance of Lymph Node Micrometastasis in pN0 Gastric Cancer Patients.

Li Y, Wang D, Li Y, Liu X, Chen D, Yuan C Gastroenterol Res Pract. 2021; 2021:6854646.

PMID: 33747076 PMC: 7946449. DOI: 10.1155/2021/6854646.

Occult Tumour Cells in Lymph Nodes from Gastric Cancer Patients: Should Isolated Tumour Cells Also Be Considered?.

Tavares A, Wen X, Maciel J, Carneiro F, Dinis-Ribeiro M Ann Surg Oncol. 2020; 27(11):4204-4215.

PMID: 32367500 DOI: 10.1245/s10434-020-08524-4.

Prognostic Significance of Solitary Lymphnode Metastasis and Micrometastasis in Gastric Cancer.

Mpallas K, Lagopoulos V, Kamparoudis A Front Surg. 2018; 5:63.

PMID: 30406109 PMC: 6200848. DOI: 10.3389/fsurg.2018.00063.

New evidence guiding extent of lymphadenectomy for esophagogastric junction tumor: Application of Ber-Ep4 Joint with CD44v6 staining on the detection of lower mediastinal lymph node micrometastasis and survival analysis.

Zheng B, Ni C, Chen H, Wu W, Guo Z, Zhu Y Medicine (Baltimore). 2017; 96(14):e6533.

PMID: 28383418 PMC: 5411202. DOI: 10.1097/MD.0000000000006533.

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