Give Progesterone a Chance

Overview

Journal Neural Regen Res

Date 2014 Oct 16

PMID 25317151

Citations 6

Authors

Florencia Labombarda

Daniel Garcia-Ovejero

Affiliations

Soon will be listed here.

Abstract

There is currently no standard pharmacological treatment for spinal cord injury. Here, we suggest that progesterone, a steroid hormone, may be a promising therapeutical candidate as it is already for traumatic brain injury, where it has reached phase II clinical trials. We rely on previous works showing anti-inflammatory, neuroprotective and promyelinating roles for progesterone after spinal cord injury and in our recent paper, in which we demonstrate that progesterone diminishes lesion, preserves white matter integrity and improves locomotor recovery in a clinically relevant model of spinal cord lesion.

Citing Articles

Hormonal Regulation of Oligodendrogenesis II: Implications for Myelin Repair.

Breton J, Long K, Barraza M, Perloff O, Kaufer D Biomolecules. 2021; 11(2).

PMID: 33669242 PMC: 7919830. DOI: 10.3390/biom11020290.

Progesterone through Progesterone Receptor B Isoform Promotes Rodent Embryonic Oligodendrogenesis.

Gonzalez-Orozco J, Del Moral-Morales A, Camacho-Arroyo I Cells. 2020; 9(4).

PMID: 32295179 PMC: 7226962. DOI: 10.3390/cells9040960.

McCallum-Loudeac J, Anderson G, Wilson M J Mol Neurosci. 2019; 69(3):419-432.

PMID: 31267314 DOI: 10.1007/s12031-019-01371-3.

Sex steroid hormones and brain function: PET imaging as a tool for research.

Moraga-Amaro R, van Waarde A, Doorduin J, de Vries E J Neuroendocrinol. 2017; 30(2).

PMID: 29237239 PMC: 5838537. DOI: 10.1111/jne.12565.

TRPV1 may increase the effectiveness of estrogen therapy on neuroprotection and neuroregeneration.

Ramirez-Barrantes R, Marchant I, Olivero P Neural Regen Res. 2016; 11(8):1204-7.

PMID: 27651755 PMC: 5020806. DOI: 10.4103/1673-5374.189162.

References

Labombarda F, Gonzalez S, Lima A, Roig P, Guennoun R, Schumacher M . Effects of progesterone on oligodendrocyte progenitors, oligodendrocyte transcription factors, and myelin proteins following spinal cord injury. Glia. 2008; 57(8):884-97. DOI: 10.1002/glia.20814. View

McConeghy K, Hatton J, Hughes L, Cook A . A review of neuroprotection pharmacology and therapies in patients with acute traumatic brain injury. CNS Drugs. 2012; 26(7):613-36. DOI: 10.2165/11634020-000000000-00000. View

Schucht P, Raineteau O, Schwab M, Fouad K . Anatomical correlates of locomotor recovery following dorsal and ventral lesions of the rat spinal cord. Exp Neurol. 2002; 176(1):143-53. DOI: 10.1006/exnr.2002.7909. View

Lammertse D . Clinical trials in spinal cord injury: lessons learned on the path to translation. The 2011 International Spinal Cord Society Sir Ludwig Guttmann Lecture. Spinal Cord. 2012; 51(1):2-9. DOI: 10.1038/sc.2012.137. View

Hurlbert R . The role of steroids in acute spinal cord injury: an evidence-based analysis. Spine (Phila Pa 1976). 2002; 26(24 Suppl):S39-46. DOI: 10.1097/00007632-200112151-00009. View

Schroeder G, Kwon B, Eck J, Savage J, Hsu W, Patel A . Survey of Cervical Spine Research Society members on the use of high-dose steroids for acute spinal cord injuries. Spine (Phila Pa 1976). 2014; 39(12):971-7. DOI: 10.1097/BRS.0000000000000297. View

Kloos A, Fisher L, Detloff M, Hassenzahl D, Basso D . Stepwise motor and all-or-none sensory recovery is associated with nonlinear sparing after incremental spinal cord injury in rats. Exp Neurol. 2005; 191(2):251-65. DOI: 10.1016/j.expneurol.2004.09.016. View

Joosten E, Veldhuis W, Hamers F . Collagen containing neonatal astrocytes stimulates regrowth of injured fibers and promotes modest locomotor recovery after spinal cord injury. J Neurosci Res. 2004; 77(1):127-42. DOI: 10.1002/jnr.20088. View

Baptiste D, Fehlings M . Pharmacological approaches to repair the injured spinal cord. J Neurotrauma. 2006; 23(3-4):318-34. DOI: 10.1089/neu.2006.23.318. View

10.

Fee D, Swartz K, Joy K, Roberts K, Scheff N, Scheff S . Effects of progesterone on experimental spinal cord injury. Brain Res. 2007; 1137(1):146-52. DOI: 10.1016/j.brainres.2006.12.024. View

11.

Koopmans G, Deumens R, Honig W, Hamers F, Steinbusch H, Joosten E . The assessment of locomotor function in spinal cord injured rats: the importance of objective analysis of coordination. J Neurotrauma. 2005; 22(2):214-25. DOI: 10.1089/neu.2005.22.214. View

12.

Basso D . Behavioral testing after spinal cord injury: congruities, complexities, and controversies. J Neurotrauma. 2004; 21(4):395-404. DOI: 10.1089/089771504323004548. View

13.

Rabchevsky A, Patel S, Springer J . Pharmacological interventions for spinal cord injury: where do we stand? How might we step forward?. Pharmacol Ther. 2011; 132(1):15-29. DOI: 10.1016/j.pharmthera.2011.05.001. View

14.

Basso D, Beattie M, Bresnahan J . Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol. 1996; 139(2):244-56. DOI: 10.1006/exnr.1996.0098. View

15.

Silva N, Sousa N, Reis R, Salgado A . From basics to clinical: a comprehensive review on spinal cord injury. Prog Neurobiol. 2013; 114:25-57. DOI: 10.1016/j.pneurobio.2013.11.002. View

16.

Beauchamp K, Mutlak H, Smith W, Shohami E, Stahel P . Pharmacology of traumatic brain injury: where is the "golden bullet"?. Mol Med. 2008; 14(11-12):731-40. PMC: 2527342. DOI: 10.2119/2008-00050.Beauchamp. View

17.

Pettus E, Wright D, Stein D, Hoffman S . Progesterone treatment inhibits the inflammatory agents that accompany traumatic brain injury. Brain Res. 2005; 1049(1):112-9. DOI: 10.1016/j.brainres.2005.05.004. View

18.

Dolan S, Nolan A . Blockade of metabotropic glutamate receptor 5 activation inhibits mechanical hypersensitivity following abdominal surgery. Eur J Pain. 2006; 11(6):644-51. DOI: 10.1016/j.ejpain.2006.10.002. View

19.

Clarac F . Some historical reflections on the neural control of locomotion. Brain Res Rev. 2007; 57(1):13-21. DOI: 10.1016/j.brainresrev.2007.07.015. View

20.

Garcia-Ovejero D, Gonzalez S, Paniagua-Torija B, Lima A, Molina-Holgado E, De Nicola A . Progesterone reduces secondary damage, preserves white matter, and improves locomotor outcome after spinal cord contusion. J Neurotrauma. 2014; 31(9):857-71. PMC: 3996974. DOI: 10.1089/neu.2013.3162. View