Recent Advances in the Optimization of Cardiac Resynchronization Therapy

Overview

Journal Curr Heart Fail Rep

Publisher Current Science

Date 2014 Oct 16

PMID 25315038

Citations 1

Authors

Satish Chandraprakasam

Gina G Mentzer

Affiliations

Soon will be listed here.

Abstract

Heart failure (HF) continues to grow and affect more than five million people in the USA. One of the leading device therapies in HF is cardiac resynchronization therapy (CRT) which has been studied for over 20 years. Recent advancements in lead placement, lead technology, patient selection, and CRT optimization by electrical maneuvers and imaging modalities have improved outcomes in morbidity, hospitalization reductions and mortalities in those who have responded CRT therapy. This review article is intended to discuss the mechanisms and benefits of CRT, clinical trials, and guidelines for CRT along with a focus on recent updates from the past 3 to 5 years and glimpse into future directions.

Citing Articles

Developments in Cardiac Resynchronisation Therapy.

Lewis G, Gold M Arrhythm Electrophysiol Rev. 2016; 4(2):122-8.

PMID: 26835113 PMC: 4711555. DOI: 10.15420/aer.2015.04.02.122.

References

De Maria R, Landolina M, Gasparini M, Schmitz B, Campolo J, Parolini M . Genetic variants of the renin-angiotensin-aldosterone system and reverse remodeling after cardiac resynchronization therapy. J Card Fail. 2012; 18(10):762-8. DOI: 10.1016/j.cardfail.2012.07.008. View

Palaniswamy C, Mishkin A, Aronow W, Kalra A, Frishman W . Remote patient monitoring in chronic heart failure. Cardiol Rev. 2012; 21(3):141-50. DOI: 10.1097/CRD.0b013e318276198b. View

Kahwash R, Burkhoff D, Abraham W . Cardiac contractility modulation in patients with advanced heart failure. Expert Rev Cardiovasc Ther. 2013; 11(5):635-45. DOI: 10.1586/erc.13.48. View

Elencwajg B, Lopez Cabanillas N, Cardinali E, Barisani J, Trainini J, Fischer A . The Jurdham procedure: endocardial left ventricular lead insertion via a femoral transseptal sheath for cardiac resynchronization therapy pectoral device implantation. Heart Rhythm. 2012; 9(11):1798-804. DOI: 10.1016/j.hrthm.2012.07.010. View

Tracy C, Epstein A, Darbar D, DiMarco J, Dunbar S, Estes 3rd N . 2012 ACCF/AHA/HRS Focused Update of the 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Heart Rhythm. 2012; 9(10):1737-53. DOI: 10.1016/j.hrthm.2012.08.021. View

Wilensky R, Yudelman P, Cohen A, FLETCHER R, Atkinson J, Virmani R . Serial electrocardiographic changes in idiopathic dilated cardiomyopathy confirmed at necropsy. Am J Cardiol. 1988; 62(4):276-83. DOI: 10.1016/0002-9149(88)90225-1. View

Tan T, Sindone A, Denniss A . Cardiac electronic implantable devices in the treatment of heart failure. Heart Lung Circ. 2012; 21(6-7):338-51. DOI: 10.1016/j.hlc.2012.03.124. View

Penicka M, Bartunek J, De Bruyne B, Vanderheyden M, Goethals M, DE Zutter M . Improvement of left ventricular function after cardiac resynchronization therapy is predicted by tissue Doppler imaging echocardiography. Circulation. 2004; 109(8):978-83. DOI: 10.1161/01.CIR.0000116765.43251.D7. View

Wilcox J, Fonarow G, Zhang Y, Albert N, Curtis A, Gheorghiade M . Clinical effectiveness of cardiac resynchronization and implantable cardioverter-defibrillator therapy in men and women with heart failure: findings from IMPROVE HF. Circ Heart Fail. 2013; 7(1):146-53. DOI: 10.1161/CIRCHEARTFAILURE.113.000789. View

10.

Healey J, Hohnloser S, Exner D, Birnie D, Parkash R, Connolly S . Cardiac resynchronization therapy in patients with permanent atrial fibrillation: results from the Resynchronization for Ambulatory Heart Failure Trial (RAFT). Circ Heart Fail. 2012; 5(5):566-70. DOI: 10.1161/CIRCHEARTFAILURE.112.968867. View

11.

Kirk J, Holewinski R, Kooij V, Agnetti G, Tunin R, Witayavanitkul N . Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β. J Clin Invest. 2013; 124(1):129-38. PMC: 3871225. DOI: 10.1172/JCI69253. View

12.

Kiani J, Agarwal S, Kamireddy S, Adelstein E, Saba S . Relationship of electro-mechanical remodeling to survival rates after cardiac resynchronization therapy. Tex Heart Inst J. 2013; 40(3):268-73. PMC: 3709225. View

13.

Yancy C, Jessup M, Bozkurt B, Butler J, Casey Jr D, Drazner M . 2013 ACCF/AHA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2013; 128(16):1810-52. DOI: 10.1161/CIR.0b013e31829e8807. View

14.

Kuperstein R, Goldenberg I, Moss A, Solomon S, Bourgoun M, Shah A . Left atrial volume and the benefit of cardiac resynchronization therapy in the MADIT-CRT trial. Circ Heart Fail. 2013; 7(1):154-60. DOI: 10.1161/CIRCHEARTFAILURE.113.000748. View

15.

Kuhne M, Bocchiardo M, Nagele H, Schaer B, Lippert M, Sticherling C . Noninvasive monitoring of stroke volume with resynchronization devices in patients with ischemic cardiomyopathy. J Card Fail. 2013; 19(8):577-82. DOI: 10.1016/j.cardfail.2013.06.005. View

16.

Pezzali N, Curnis A, Specchia C, Carubelli V, Covolo L, Donato F . Adrenergic receptor gene polymorphism and left ventricular reverse remodelling after cardiac resynchronization therapy: preliminary results. Europace. 2013; 15(10):1475-81. DOI: 10.1093/europace/eut136. View

17.

Ogano M, Iwasaki Y, Tanabe J, Takagi H, Umemoto T, Hayashi M . Antiarrhythmic effect of cardiac resynchronization therapy with triple-site biventricular stimulation. Europace. 2013; 15(10):1491-8. DOI: 10.1093/europace/eut134. View

18.

Lumens J, Ploux S, Strik M, Gorcsan 3rd J, Cochet H, Derval N . Comparative electromechanical and hemodynamic effects of left ventricular and biventricular pacing in dyssynchronous heart failure: electrical resynchronization versus left-right ventricular interaction. J Am Coll Cardiol. 2013; 62(25):2395-2403. PMC: 3985285. DOI: 10.1016/j.jacc.2013.08.715. View

19.

Zocalo Y, Bia D, Armentano R, Gonzalez-Moreno J, Varela G, Calleriza F . Resynchronization improves heart-arterial coupling reducing arterial load determinants. Europace. 2012; 15(4):554-65. DOI: 10.1093/europace/eus285. View

20.

Wang H, Li X, Zhang H, Sun S . Left ventricular endocardial leadless pacing brings new hope to patients with heart failure. Int J Cardiol. 2012; 167(3):1073-4. DOI: 10.1016/j.ijcard.2012.10.064. View