Translational Control in Germline Stem Cell Development

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2014 Oct 15

PMID 25313405

Citations 50

Authors

Maija Slaidina

Ruth Lehmann

Affiliations

Soon will be listed here.

Abstract

Stem cells give rise to tissues and organs during development and maintain their integrity during adulthood. They have the potential to self-renew or differentiate at each division. To ensure proper organ growth and homeostasis, self-renewal versus differentiation decisions need to be tightly controlled. Systematic genetic studies in Drosophila melanogaster are revealing extensive regulatory networks that control the switch between stem cell self-renewal and differentiation in the germline. These networks, which are based primarily on mutual translational repression, act via interlocked feedback loops to provide robustness to this important fate decision.

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