Side and Type of Initial Motor Symptom Influences Visuospatial Functioning in Parkinson's Disease

Overview

Journal J Parkinsons Dis

Publisher Sage Publications

Specialty Neurology

Date 2014 Oct 15

PMID 25311203

Citations 11

Authors

Daniel R Seichepine

Sandy Neargarder

Sigurros Davidsdottir

Gretchen O Reynolds

Alice Cronin-Golomb

Affiliations

Soon will be listed here.

Abstract

Background/objectives: Visuospatial problems are common in Parkinson's disease (PD) and likely stem from dysfunction in dopaminergic pathways and consequent disruption of cortical functioning. Characterizing the motor symptoms at disease onset provides a method of observing how dysfunction in these pathways influences visuospatial cognition. We examined two types of motor characteristics: Body side (left or right) and type of initial symptom (tremor or symptom other than tremor).

Methods: 31 non-demented patients with PD, 16 with left-side onset (LPD) and 15 with right-side onset (RPD), as well as 17 healthy control participants (HC). The PD group was also divided by type of initial motor symptom, 15 having tremor as the initial symptom and 16 having an initial symptom other than tremor. Visuospatial function was assessed with the Clock Drawing Test.

Results: Of the four Clock Drawing scoring methods used, the Rouleau method showed sensitivity to subgroup differences. As predicted, the LPD and non-tremor subgroups, but not the other subgroups, performed more poorly than the HC group.

Conclusion: The findings provide further evidence for differences in cognition between these subtypes of PD and highlight the importance of considering disease subtypes when examining cognition.

Citing Articles

Visual Dysfunction in Parkinson's Disease.

Nieto-Escamez F, Obrero-Gaitan E, Cortes-Perez I Brain Sci. 2023; 13(8).

PMID: 37626529 PMC: 10452537. DOI: 10.3390/brainsci13081173.

Gray and white matter alterations in different predominant side and type of motor symptom in Parkinson's disease.

Chen J, Jiang X, Wu J, Wu H, Zhou C, Guo T CNS Neurosci Ther. 2022; 28(9):1372-1379.

PMID: 35673762 PMC: 9344082. DOI: 10.1111/cns.13877.

Taking the Time to Assess Cognition in Parkinson's Disease: The Clock Drawing Test.

Srivastava H, Joop A, Memon R, Pilkington J, Wood K, Love M J Parkinsons Dis. 2021; 12(2):713-722.

PMID: 34864688 PMC: 10913933. DOI: 10.3233/JPD-212802.

Dopaminergic Basis of Spatial Deficits in Early Parkinson's Disease.

Hanna-Pladdy B, Pahwa R, Lyons K Cereb Cortex Commun. 2021; 2(3):tgab042.

PMID: 34738086 PMC: 8436572. DOI: 10.1093/texcom/tgab042.

Severity-Dependent Effects of Parkinson's Disease on Perception of Visual and Vestibular Heading.

Beylergil S, Petersen M, Gupta P, Elkasaby M, Kilbane C, Shaikh A Mov Disord. 2020; 36(2):360-369.

PMID: 33103821 PMC: 8863488. DOI: 10.1002/mds.28352.

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