Serial Changes of Neointimal Tissue After Everolimus-eluting Stent Implantation in Porcine Coronary Artery: an Optical Coherence Tomography Analysis

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2014 Oct 14

PMID 25309929

Citations 4

Authors

Hoyoun Won

Jung-Sun Kim

Dong-Ho Shin

Byeong-Keuk Kim

Young-Guk Ko

Donghoon Choi

Yangsoo Jang

Myeong-Ki Hong

Affiliations

Soon will be listed here.

Abstract

Purposes: The serial changes in neointimal tissues were compared between everolimus-eluting stent (EES) and bare-metal stent (BMS) in the porcine coronary artery using optical coherence tomography (OCT).

Methods: Serial (1, 3, and 6 month follow-up after stent implantation) OCT examinations were performed in 15 swine with 15 BMS- and 15 EES-treated lesions in porcine coronary arteries.

Results: In BMS-implanted lesions, neointimal volume decreased from 7.3 mm(3) to 6.9 mm(3) and 6.4 mm(3) at 1, 3, and 6 months follow-up without statistical significance (P = 0.369). At the time points of 1, 3, and 6 months, neointimal tissue appearance was mainly a homogeneous pattern (80.0%, 93.3%, and 100%, resp.), while the other pattern was layered. In contrast, in EES-implanted lesions, neointimal volume significantly increased from 4.8 mm(3) to 9.8 mm(3) between 1 and 3 months but significantly decreased to 8.6 mm(3) between 3 and 6 months (P < 0.001). Between 1 and 3 months, the layered pattern of neointimal tissue increased from 26.7% to 66.7% but decreased to 20.0% between 3 and 6 months.

Conclusions: EES had a biphasic pattern of neointimal amounts that correlated with changes in neointimal morphology.

Citing Articles

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Corrigendum to "Serial Changes of Neointimal Tissue after Everolimus-Eluting Stent Implantation in Porcine Coronary Artery: An Optical Coherence Tomography Analysis".

Won H, Kim J, Shin D, Kim B, Ko Y, Choi D Biomed Res Int. 2019; 2019:8629375.

PMID: 31871944 PMC: 6906840. DOI: 10.1155/2019/8629375.

Common swine models of cardiovascular disease for research and training.

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