Combined Aerobic and Resistance Exercise Training Decreases Peripheral but Not Central Artery Wall Thickness in Subjects with Type 2 Diabetes

Overview

Journal Eur J Appl Physiol

Specialty Physiology

Date 2014 Oct 14

PMID 25308877

Citations 3

Authors

Tim H A Schreuder

Inge van den Munckhof

Fleur Poelkens

Maria T E Hopman

Dick H J Thijssen

Affiliations

Soon will be listed here.

Abstract

Objective: Little is known about the impact of exercise training on conduit artery wall thickness in type 2 diabetes. We examined the local and systemic impact of exercise training on superficial femoral (SFA), brachial (BA), and carotid artery (CA) wall thickness in type 2 diabetes patients and controls.

Methods: Twenty patients with type 2 diabetes and 10 age- and sex-matched controls performed an 8-week training study involving lower limb-based combined aerobic and resistance exercise training. We examined the SFA to study the local effect of exercise, and also the systemic impact of lower limb-based exercise training on peripheral (i.e. BA) and central (i.e. CA) arteries. Wall thickness (WT), diameter and wall:lumen(W:L)-ratios were examined using automated edge detection of ultrasound images.

Results: Exercise training did not alter SFA or CA diameter in type 2 diabetes or controls (all P > 0.05). BA diameter was increased after training in type 2 diabetes, but not in controls. Exercise training decreased WT and W:L ratio in the SFA and BA, but not in CA in type 2 diabetes. Training did not alter WT or W:L ratio in controls (P > 0.05).

Conclusion: Lower limb-dominant exercise training causes remodelling of peripheral arteries, supplying active and inactive vascular beds, but not central arteries in type 2 diabetes.

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