Palladium-catalyzed Debenzylative Cross-coupling of Aryl Benzyl Sulfides with Aryl Bromides: Synthesis of Diaryl Sulfides

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2014 Oct 10

PMID 25298227

Citations 7

Authors

Jianyou Mao

Tiezheng Jia

Gustavo Frensch

Patrick J Walsh

Affiliations

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Abstract

A novel debenzylative approach to synthesize diaryl sulfides from aryl benzyl sulfides and aryl bromides in good to excellent yields is reported. Mechanistic studies suggest a single catalyst, derived from Pd(dba)2 and NiXantPhos, efficiently catalyzes α-arylation of sulfides, C-S bond cleavage, and C-S bond formation in a tricatalytic cycle.

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