Effects of Fructo-Oligosaccharide Supplementation on Constipation in Elderly Continuous Ambulatory Peritoneal Dialysis Patients

Overview

Journal Perit Dial Int

Publisher Sage Publications

Date 2014 Oct 9

PMID 25292404

Citations 18

Authors

Kulwara Meksawan

Chorsakon Chaotrakul

Napat Leeaphorn

Suthep Gonlchanvit

Somchai Eiam-Ong

Talerngsak Kanjanabuch

Affiliations

Soon will be listed here.

Abstract

Unlabelled: ♦

Background: Fructo-oligosaccharides (FOS) exhibit soluble-fiber properties that beneficially affect bowel function and relieve constipation. The effects of FOS supplementation on constipation and biochemical parameters were examined in elderly continuous ambulatory peritoneal dialysis (CAPD) patients. ♦

Methods: This randomized, double-blind, placebo-controlled, cross-over study was performed in elderly CAPD patients (5 males and 4 females) with chronic constipation. All subjects were randomly assigned to receive either 20 g FOS or placebo daily for 30 days. After a 14-day washout period, the patients were switched to the other substance for 1 more month. Before and after each treatment period, frequency of defecation, characteristics of feces, and colonic transit were evaluated. Biochemical parameters were also assessed. ♦

Results: Fructo-oligosaccharides significantly increased the frequency of defecation (10.5 ± 2.0 vs 6.2 ± 1.4 times per week, p < 0.005) and changed the feces' appearance from type 1 (nut-like) to type 4 (sausage-like). The colonic transit determined by geometric center (GC) was augmented after FOS supplementation (3.9 ± 0.3 vs 3.2 ± 0.4, p < 0.05). Fructo-oligosaccharides had no effects on biochemical parameters. Fructo-oligosaccharides caused mild discomforts which were well tolerated after dose adjustment. ♦

Conclusions: Fructo-oligosaccharide supplementation is effective, well tolerated, and can be an alternative to other laxatives in CAPD patients with constipation. Further studies are needed to better assess the biochemical effects of FOS in the chronic kidney disease population.

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References

Slavin J . Dietary fiber and body weight. Nutrition. 2005; 21(3):411-8. DOI: 10.1016/j.nut.2004.08.018. View

Sanwalka N, Khadilkar A, Chiplonkar S, Khadilkar V, Mughal M . Galacto-fructo-oligosaccharide fortification of fermented non-dairy snack enhances calcium absorption in healthy adolescent girls. Int J Food Sci Nutr. 2011; 63(3):343-52. DOI: 10.3109/09637486.2011.627848. View

Yasuda G, Shibata K, Takizawa T, Ikeda Y, Tokita Y, Umemura S . Prevalence of constipation in continuous ambulatory peritoneal dialysis patients and comparison with hemodialysis patients. Am J Kidney Dis. 2002; 39(6):1292-9. DOI: 10.1053/ajkd.2002.33407. View

Liu L . Chronic constipation: current treatment options. Can J Gastroenterol. 2011; 25 Suppl B:22B-28B. PMC: 3206558. View

Younes H, Alphonse J, Hadj-Abdelkader M, Remesy C . Fermentable carbohydrate and digestive nitrogen excretion. J Ren Nutr. 2001; 11(3):139-48. DOI: 10.1053/jren.2001.24359. View

Lembo A, Camilleri M . Chronic constipation. N Engl J Med. 2003; 349(14):1360-8. DOI: 10.1056/NEJMra020995. View

Geboes K, De Hertogh G, De Preter V, Luypaerts A, Bammens B, Evenepoel P . The influence of inulin on the absorption of nitrogen and the production of metabolites of protein fermentation in the colon. Br J Nutr. 2006; 96(6):1078-86. DOI: 10.1017/bjn20061936. View

Cashman K . Prebiotics and calcium bioavailability. Curr Issues Intest Microbiol. 2003; 4(1):21-32. View

Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F . Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals. Clin Nutr. 2004; 23(3):331-40. DOI: 10.1016/j.clnu.2003.07.010. View

10.

Bouhnik Y, Raskine L, Simoneau G, Paineau D, Bornet F . The capacity of short-chain fructo-oligosaccharides to stimulate faecal bifidobacteria: a dose-response relationship study in healthy humans. Nutr J. 2006; 5:8. PMC: 1448190. DOI: 10.1186/1475-2891-5-8. View

11.

Luo J, Rizkalla S, ALAMOWITCH C, Boussairi A, Blayo A, BARRY J . Chronic consumption of short-chain fructooligosaccharides by healthy subjects decreased basal hepatic glucose production but had no effect on insulin-stimulated glucose metabolism. Am J Clin Nutr. 1996; 63(6):939-45. DOI: 10.1093/ajcn/63.6.939. View

12.

Coudray C, Bellanger J, Remesy C, Vermorel M, Rayssignuier Y . Effect of soluble or partly soluble dietary fibres supplementation on absorption and balance of calcium, magnesium, iron and zinc in healthy young men. Eur J Clin Nutr. 1997; 51(6):375-80. DOI: 10.1038/sj.ejcn.1600417. View

13.

Hardy J, Perkins A . Validity of the geometric mean correction in the quantification of whole bowel transit. Nucl Med Commun. 1985; 6(4):217-24. DOI: 10.1097/00006231-198504000-00005. View

14.

Chen H, Lu Y, Lin J, Ko L . Effects of isomalto-oligosaccharides on bowel functions and indicators of nutritional status in constipated elderly men. J Am Coll Nutr. 2001; 20(1):44-9. DOI: 10.1080/07315724.2001.10719013. View

15.

van den Heuvel E, Muys T, van Dokkum W, Schaafsma G . Oligofructose stimulates calcium absorption in adolescents. Am J Clin Nutr. 1999; 69(3):544-8. DOI: 10.1093/ajcn/69.3.544. View

16.

Yen C, Kuo Y, Tseng Y, Lee M, Chen H . Beneficial effects of fructo-oligosaccharides supplementation on fecal bifidobacteria and index of peroxidation status in constipated nursing-home residents--a placebo-controlled, diet-controlled trial. Nutrition. 2010; 27(3):323-8. DOI: 10.1016/j.nut.2010.02.009. View

17.

Roberfroid M . Fructo-oligosaccharide malabsorption: benefit for gastrointestinal functions. Curr Opin Gastroenterol. 2006; 16(2):173-7. DOI: 10.1097/00001574-200003000-00013. View

18.

Mimidis K, Mourvati E, Kaliontzidou M, Papadopoulos V, Thodis E, Kartalis G . Efficacy of polyethylene glycol in constipated CAPD patients. Perit Dial Int. 2006; 25(6):601-3. View

19.

Afsar B, Elsurer R, Bilgic A, Sezer S, Ozdemir F . Regular lactulose use is associated with lower peritonitis rates: an observational study. Perit Dial Int. 2010; 30(2):243-6. DOI: 10.3747/pdi.2009.00035. View

20.

Attar A, Lemann M, Ferguson A, Halphen M, Boutron M, Flourie B . Comparison of a low dose polyethylene glycol electrolyte solution with lactulose for treatment of chronic constipation. Gut. 1999; 44(2):226-30. PMC: 1727381. DOI: 10.1136/gut.44.2.226. View