Gene Expression in Colorectal Cancer: A Novel Marker for Prognosis

Overview

Journal Oncol Lett

Specialty Oncology

Date 2014 Oct 8

PMID 25289111

Citations 15

Authors

Norikatsu Miyoshi

Hirofumi Yamamoto

Koshi Mimori

Shinya Yamashita

Susumu Miyazaki

Sumiko Nakagawa

Hideshi Ishii

Shingo Noura

Masayuki Ohue

Masahiko Yano

Yuichiro Doki

Masaki Mori

Affiliations

Soon will be listed here.

Abstract

Annexin A9 () is involved with the interaction with membrane phospholipids in a Ca-dependent manner. A previous study has shown that expression is associated with bone metastasis in breast cancer, whereas its significance in colorectal cancer (CRC) is unknown. The present study was comprised of 100 patients who underwent surgery for CRC. The correlation between gene expression and the clinical parameters of the patients was assessed. Patients with high expression were statistically susceptible to a relatively worse prognosis, and those with low expression showed improved overall survival compared with those with high expression. In conclusion, the present data suggests that expression is a prognostic factor in CRC patients.

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