Association Between Single Nucleotide Polymorphisms in the ADD3 Gene and Susceptibility to Biliary Atresia

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Oct 7

PMID 25285724

Citations 13

Authors

Shuaidan Zeng

Peng Sun

Zimin Chen

Jianxiong Mao

Jianyao Wang

Bin Wang

Lei Liu

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: Based on the results of previous studies, the ADD3 gene, located in the 10q24.2 region, may be a susceptibility gene of biliary atresia (BA). In this study, two single nucleotide polymorphisms (SNPs) in the ADD3 gene, rs17095355 C/T and rs10509906 G/C, were selected to investigate whether there is an association between these SNPs and susceptibility to BA in a Chinese population.

Methods: A total of 752 Han Chinese (134 BA cases and 618 ethnically matched healthy controls) were included in the present study. The ADD3 gene polymorphisms were genotyped using a TaqMan genotyping assay.

Results: Positive associations were found for the SNP rs17095355 in the codominant model; specifically, the frequencies of the CT and TT genotypes and the T allele were higher in the cases than the controls, demonstrating a significant risk for BA (odds ratio [OR] = 1.62, 95% confidence interval [CI] = 1.02-2.58; OR = 2.89, 95% CI = 1.72-4.86; and OR = 1.75, 95% CI = 1.34-2.29, respectively). Regarding rs10509906, the per-C-allele conferred an OR of 0.70 (95% CI = 0.49-1.00) under the additive model. A greater risk of BA was associated with the T(a)-G(b) (a for rs17095355 and b for rs10509906) haplotype (OR = 1.82, 95% CI = 1.27-2.61) compared with the C(a)-C(b) haplotype.

Conclusion: This study suggests that the ADD3 gene plays an important role in BA pathogenesis and reveals a significant association between two SNPs, rs17095355 and rs10509906, and BA.

Citing Articles

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Biliary atresia.

Tam P, Wells R, Tang C, Lui V, Hukkinen M, Luque C Nat Rev Dis Primers. 2024; 10(1):47.

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Ye Y, Wu W, Zheng J, Zhang L, Wang B Bioengineered. 2022; 13(3):6222-6230.

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References

Udomsinprasert W, Tencomnao T, Honsawek S, Anomasiri W, Vejchapipat P, Chongsrisawat V . +276 G/T single nucleotide polymorphism of the adiponectin gene is associated with the susceptibility to biliary atresia. World J Pediatr. 2012; 8(4):328-34. DOI: 10.1007/s12519-012-0377-x. View

Garcia-Barcelo M, Yeung M, Miao X, Tang C, Cheng G, Chen G . Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2. Hum Mol Genet. 2010; 19(14):2917-25. PMC: 2893814. DOI: 10.1093/hmg/ddq196. View

Silveira T, Salzano F, Donaldson P, Mieli-Vergani G, Howard E, Mowat A . Association between HLA and extrahepatic biliary atresia. J Pediatr Gastroenterol Nutr. 1993; 16(2):114-7. DOI: 10.1097/00005176-199302000-00002. View

Oshio C, Phillips M . Contractility of bile canaliculi: implications for liver function. Science. 1981; 212(4498):1041-2. DOI: 10.1126/science.7015506. View

Suskind D, Rosenthal P, Heyman M, Kong D, Magrane G, Baxter-Lowe L . Maternal microchimerism in the livers of patients with biliary atresia. BMC Gastroenterol. 2004; 4:14. PMC: 514704. DOI: 10.1186/1471-230X-4-14. View

Fischler B, Ehrnst A, Forsgren M, Orvell C, Nemeth A . The viral association of neonatal cholestasis in Sweden: a possible link between cytomegalovirus infection and extrahepatic biliary atresia. J Pediatr Gastroenterol Nutr. 1998; 27(1):57-64. DOI: 10.1097/00005176-199807000-00010. View

Smith B, Laberge J, Schreiber R, Weber A, Blanchard H . Familial biliary atresia in three siblings including twins. J Pediatr Surg. 1991; 26(11):1331-3. DOI: 10.1016/0022-3468(91)90613-x. View

Cheng G, Tang C, Wong E, Cheng W, So M, Miao X . Common genetic variants regulating ADD3 gene expression alter biliary atresia risk. J Hepatol. 2013; 59(6):1285-91. DOI: 10.1016/j.jhep.2013.07.021. View

Kaewkiattiyot S, Honsawek S, Vejchapipat P, Chongsrisawat V, Poovorawan Y . Association of X-prolyl aminopeptidase 1 rs17095355 polymorphism with biliary atresia in Thai children. Hepatol Res. 2011; 41(12):1249-52. DOI: 10.1111/j.1872-034X.2011.00870.x. View

10.

Zhao R, Song Z, Dong R, Li H, Shen C, Zheng S . Polymorphism of ITGB2 gene 3'-UTR+145C/A is associated with biliary atresia. Digestion. 2013; 88(2):65-71. DOI: 10.1159/000352025. View

11.

Arikan C, Berdeli A, Kilic M, Tumgor G, Yagci R, Aydogdu S . Polymorphisms of the ICAM-1 gene are associated with biliary atresia. Dig Dis Sci. 2008; 53(7):2000-4. DOI: 10.1007/s10620-007-9914-1. View

12.

Shteyer E, Ramm G, Xu C, White F, Shepherd R . Outcome after portoenterostomy in biliary atresia: pivotal role of degree of liver fibrosis and intensity of stellate cell activation. J Pediatr Gastroenterol Nutr. 2005; 42(1):93-9. DOI: 10.1097/01.mpg.0000189324.80323.a6. View

13.

Naydenov N, Ivanov A . Adducins regulate remodeling of apical junctions in human epithelial cells. Mol Biol Cell. 2010; 21(20):3506-17. PMC: 2954116. DOI: 10.1091/mbc.E10-03-0259. View

14.

Vijayan V, El Tan C . Computer-generated three-dimensional morphology of the hepatic hilar bile ducts in biliary atresia. J Pediatr Surg. 2000; 35(8):1230-5. DOI: 10.1053/jpsu.2000.8760. View

15.

Shih H, Lin T, Chuang J, Eng H, Juo S, Huang F . Promoter polymorphism of the CD14 endotoxin receptor gene is associated with biliary atresia and idiopathic neonatal cholestasis. Pediatrics. 2005; 116(2):437-41. DOI: 10.1542/peds.2004-1900. View

16.

Chuang J, Chou M, Wu C, Du Y . Implication of innate immunity in the pathogenesis of biliary atresia. Chang Gung Med J. 2006; 29(3):240-50. View

17.

Segawa O, Miyano T, Fujimoto T, Watanabe S, Hirose M, Fujiwara T . Actin and myosin deposition around bile canaliculi: a predictor of clinical outcome in biliary atresia. J Pediatr Surg. 1993; 28(6):851-6. DOI: 10.1016/0022-3468(93)90344-k. View

18.

Tyler K, Sokol R, Oberhaus S, Le M, Karrer F, Narkewicz M . Detection of reovirus RNA in hepatobiliary tissues from patients with extrahepatic biliary atresia and choledochal cysts. Hepatology. 1998; 27(6):1475-82. DOI: 10.1002/hep.510270603. View

19.

Arikan C, Berdeli A, Ozgenc F, Tumgor G, Yagci R, Aydogdu S . Positive association of macrophage migration inhibitory factor gene-173G/C polymorphism with biliary atresia. J Pediatr Gastroenterol Nutr. 2005; 42(1):77-82. DOI: 10.1097/01.mpg.0000192247.55583.fa. View

20.

Tsai E, Grochowski C, Loomes K, Bessho K, Hakonarson H, Bezerra J . Replication of a GWAS signal in a Caucasian population implicates ADD3 in susceptibility to biliary atresia. Hum Genet. 2013; 133(2):235-43. PMC: 3901047. DOI: 10.1007/s00439-013-1368-2. View