New Considerations on Hormetic Response Against Oxidative Stress

Overview

Journal J Cell Commun Signal

Date 2014 Oct 7

PMID 25284448

Citations 20

Authors

Armando Luna-Lopez

Viridiana Y Gonzalez-Puertos

Norma E Lopez-Diazguerrero

Mina Konigsberg

Affiliations

Soon will be listed here.

Abstract

In order to survive living organisms have developed multiple mechanisms to deal with tough environmental conditions. Hormesis is defined as a process in which exposure to a low dose of a chemical agent or environmental factor that is damaging at higher doses induces an adaptive beneficial effect on the cell or organism. In this paper, we examine several ideas that might be taken into consideration before using hormesis as a therapeutic tool to improve health and life span, and hopefully will open the discussion for new and interesting debates regard hormesis. The first one is to understand that the same stressor or inductor can activate different pathways in a parallel or dual response, which might lead to diverse outcomes. Another idea is related to the mechanisms involved in activating Nrf2, which might be different and have diverse hormetic effects.Last, we discuss mild oxidative stress in association to low-grade chronic inflammation as a stimulating avenue to be explored and the unexpected effects proposed by the obesity paradox theory. All the previous might help to clarify the reasons why centenarians are able to reach the extreme limits of human life span, which could probably be related to the way they deal with homeostasis maintenance, providing an opportunity for hormesis to intervene significantly.

Citing Articles

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Potential Defence Mechanisms Triggered by Monosodium Glutamate Sub-Chronic Consumption in Two-Year-Old Wistar Rats.

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Methotrexate Induces an Antioxidant Hormetic Response in Primary Rat Astrocytes.

Luna-Lopez A, Flores-Gonzalez G, Rivera-Ruz I, Librado-Osorio R, Erosa-De Haro L, Konigsberg M Dose Response. 2022; 20(3):15593258221130752.

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References

Erlank H, Elmann A, Kohen R, Kanner J . Polyphenols activate Nrf2 in astrocytes via H2O2, semiquinones, and quinones. Free Radic Biol Med. 2011; 51(12):2319-27. DOI: 10.1016/j.freeradbiomed.2011.09.033. View

Wakabayashi N, Itoh K, Wakabayashi J, Motohashi H, Noda S, Takahashi S . Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet. 2003; 35(3):238-45. DOI: 10.1038/ng1248. View

Xu J, Wang H, Ding K, Zhang L, Wang C, Li T . Luteolin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE pathway. Free Radic Biol Med. 2014; 71:186-195. DOI: 10.1016/j.freeradbiomed.2014.03.009. View

Mishra S, Vinayak M . Ellagic acid inhibits PKC signaling by improving antioxidant defense system in murine T cell lymphoma. Mol Biol Rep. 2014; 41(7):4187-97. DOI: 10.1007/s11033-014-3289-0. View

Kobayashi M, Yamamoto M . Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv Enzyme Regul. 2006; 46:113-40. DOI: 10.1016/j.advenzreg.2006.01.007. View

Kleszczynski K, Ernst I, Wagner A, Kruse N, Zillikens D, Rimbach G . Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes. Pharmacol Res. 2013; 78:28-40. DOI: 10.1016/j.phrs.2013.09.009. View

Satoh T, McKercher S, Lipton S . Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs. Free Radic Biol Med. 2013; 65:645-657. PMC: 3859717. DOI: 10.1016/j.freeradbiomed.2013.07.022. View

Niture S, Jaiswal A . Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis. J Biol Chem. 2012; 287(13):9873-9886. PMC: 3323009. DOI: 10.1074/jbc.M111.312694. View

Buelna-Chontal M, Guevara-Chavez J, Silva-Palacios A, Medina-Campos O, Pedraza-Chaverri J, Zazueta C . Nrf2-regulated antioxidant response is activated by protein kinase C in postconditioned rat hearts. Free Radic Biol Med. 2014; 74:145-56. DOI: 10.1016/j.freeradbiomed.2014.06.021. View

10.

Jin H, Kanthasamy A, Anantharam V, Rana A, Kanthasamy A . Transcriptional regulation of pro-apoptotic protein kinase Cdelta: implications for oxidative stress-induced neuronal cell death. J Biol Chem. 2011; 286(22):19840-59. PMC: 3103361. DOI: 10.1074/jbc.M110.203687. View

11.

Hernandez-Bautista R, Alarcon-Aguilar F, Del C Escobar-Villanueva M, Almanza-Perez J, Merino-Aguilar H, Fainstein M . Biochemical alterations during the obese-aging process in female and male monosodium glutamate (MSG)-treated mice. Int J Mol Sci. 2014; 15(7):11473-94. PMC: 4139794. DOI: 10.3390/ijms150711473. View

12.

Mukherjee S, Ghosh S, Choudhury S, Adhikary A, Manna K, Dey S . Pomegranate reverses methotrexate-induced oxidative stress and apoptosis in hepatocytes by modulating Nrf2-NF-κB pathways. J Nutr Biochem. 2013; 24(12):2040-50. DOI: 10.1016/j.jnutbio.2013.07.005. View

13.

Lee M, Wu Y, Fried S . Adipose tissue remodeling in pathophysiology of obesity. Curr Opin Clin Nutr Metab Care. 2010; 13(4):371-6. PMC: 3235038. DOI: 10.1097/MCO.0b013e32833aabef. View

14.

Song H, Oh S, Quan S, Ryu O, Jeong J, Hong K . Gender differences in adiponectin levels and body composition in older adults: Hallym aging study. BMC Geriatr. 2014; 14:8. PMC: 3931323. DOI: 10.1186/1471-2318-14-8. View

15.

Trujillo J, Chirino Y, Molina-Jijon E, Anderica-Romero A, Tapia E, Pedraza-Chaverri J . Renoprotective effect of the antioxidant curcumin: Recent findings. Redox Biol. 2013; 1:448-56. PMC: 3814973. DOI: 10.1016/j.redox.2013.09.003. View

16.

Rubio V, Valverde M, Rojas E . Effects of atmospheric pollutants on the Nrf2 survival pathway. Environ Sci Pollut Res Int. 2009; 17(2):369-82. DOI: 10.1007/s11356-009-0140-6. View

17.

Hayden A, Douglas J, Sommerlad M, Andrews L, Gould K, Hussain S . The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer. Urol Oncol. 2014; 32(6):806-14. DOI: 10.1016/j.urolonc.2014.02.006. View

18.

Rattan S . Hormetic modulation of aging and longevity by mild heat stress. Dose Response. 2008; 3(4):533-46. PMC: 2477195. DOI: 10.2203/dose-response.003.04.008. View

19.

Garcia-Nino W, Pedraza-Chaverri J . Protective effect of curcumin against heavy metals-induced liver damage. Food Chem Toxicol. 2014; 69:182-201. DOI: 10.1016/j.fct.2014.04.016. View

20.

Park S, Jang J, Chen C, Na H, Surh Y . A formulated red ginseng extract rescues PC12 cells from PCB-induced oxidative cell death through Nrf2-mediated upregulation of heme oxygenase-1 and glutamate cysteine ligase. Toxicology. 2010; 278(1):131-9. DOI: 10.1016/j.tox.2010.04.003. View