Combination of MicroRNA Therapeutics with Small-molecule Anticancer Drugs: Mechanism of Action and Co-delivery Nanocarriers

Overview

Journal Adv Drug Deliv Rev

Specialty Pharmacology

Date 2014 Oct 5

PMID 25281917

Citations 61

Authors

Xin Dai

Chalet Tan

Affiliations

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Abstract

MicroRNAs (miRNAs) regulate multiple molecular pathways vital for the hallmarks of cancer with a high degree of biochemical specificity and potency. By restoring tumor suppressive miRNAs or ablating oncomiRs, miRNA-based therapies can sensitize cancer cells to conventional cytotoxins and the molecularly targeted drugs by promoting apoptosis and autophagy, reverting epithelial-to-mesenchymal transition, suppressing tumor angiogenesis, and downregulating efflux transporters. The development of miRNA-based therapeutics in combination with small-molecule anticancer drugs provides an unprecedented opportunity to counteract chemoresistance and improve treatment outcome in a broad range of human cancers. This review summarizes the mechanisms and advantages for the combination therapies involving miRNAs and small-molecule drugs, as well as the recent advances in the co-delivery nanocarriers for these agents.

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