Increased Pyrethroid Resistance in Malaria Vectors and Decreased Bed Net Effectiveness, Burkina Faso

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2014 Oct 4

PMID 25279965

Citations 143

Authors

Kobie H Toe

Christopher M Jones

Sagnon NFale

Hanafy M Ismail

Roch K Dabire

Hilary Ranson

Affiliations

Soon will be listed here.

Abstract

Malaria control is dependent on insecticides. Increases in prevalence of insecticide resistance in malaria vectors across Africa are well-documented. However, few attempts have been made to quantify the strength of this resistance and link it to the effectiveness of control tools. Using quantitative bioassays, we show that in Burkina Faso pyrethroid resistance in Anopheles gambiae mosquitoes has increased in intensity in recent years and now exceeds 1,000-fold. In laboratory assays, this level of resistance renders insecticides used to impregnate bed nets ineffective. Thus, the level of personal and community protection afforded by long-lasting insecticide-treated net campaigns will probably be reduced. Standardized methods are needed to quantify resistance levels in malaria vectors and link these levels to failure of vector control methods.

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