Effects of Vitamin D in the Elderly Population: Current Status and Perspectives

Overview

Journal Arch Public Health

Publisher Biomed Central

Date 2014 Oct 4

PMID 25279143

Citations 35

Authors

Olivier Bruyere

Etienne Cavalier

Jean-Claude Souberbielle

Heike A Bischoff-Ferrari

Charlotte Beaudart

Fanny Buckinx

Jean-Yves Reginster

Rene Rizzoli

Affiliations

Soon will be listed here.

Abstract

Besides its well-known effect on bone metabolism, recent researches suggest that vitamin D may also play a role in the muscular, immune, endocrine, and central nervous systems. Double-blind RCTs support vitamin D supplementation at a dose of 800 IU per day for the prevention of falls and fractures in the senior population. Ecological, case-control and cohort studies have suggested that high vitamin D levels were associated with a reduced risk of autoimmune diseases, type 2 diabetes, cardio-vascular diseases and cancer but large clinical trials are lacking today to provide solid evidence of a vitamin D benefit beyond bone health. At last, the optimal dose, route of administration, dosing interval and duration of vitamin D supplementation at a specific target dose beyond the prevention of vitamin D deficiency need to be further investigated.

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