BioAge: Toward a Multi-determined, Mechanistic Account of Cognitive Aging

Overview

Journal Ageing Res Rev

Specialty Geriatrics

Date 2014 Oct 4

PMID 25278166

Citations 15

Authors

Correne A DeCarlo

Holly A Tuokko

Dorothy Williams

Roger A Dixon

Stuart W S MacDonald

Affiliations

Soon will be listed here.

Abstract

The search for reliable early indicators of age-related cognitive decline represents a critical avenue for progress in aging research. Chronological age is a commonly used developmental index; however, it offers little insight into the mechanisms underlying cognitive decline. In contrast, biological age (BioAge), reflecting the vitality of essential biological systems, represents a promising operationalization of developmental time. Current BioAge models have successfully predicted age-related cognitive deficits. Research on aging-related cognitive function indicates that the interaction of multiple risk and protective factors across the human lifespan confers individual risk for late-life cognitive decline, implicating a multi-causal explanation. In this review, we explore current BioAge models, describe three broad yet pathologically relevant biological processes linked to cognitive decline, and propose a novel operationalization of BioAge accounting for both moderating and causal mechanisms of cognitive decline and dementia. We argue that a multivariate and mechanistic BioAge approach will lead to a greater understanding of disease pathology as well as more accurate prediction and early identification of late-life cognitive decline.

Citing Articles

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