T Cell Immune Abnormalities in Immune Thrombocytopenia

Overview

Journal J Hematol Oncol

Publisher Biomed Central

Specialties Hematology
Oncology

Date 2014 Oct 3

PMID 25274611

Citations 29

Authors

Xuebin Ji

Liping Zhang

Jun Peng

Ming Hou

Affiliations

Soon will be listed here.

Abstract

Immune thrombocytopenia is an autoimmune disease with abnormal T cell immunity. Cytotoxic T cells, abnormal T regulatory cells, helper T cell imbalance, megakaryocyte maturation abnormalities and abnormal T cell anergy are involved in the pathogenesis of this condition. The loss of T cell-mediated immune tolerance to platelet auto-antigens plays a crucial role in immune thrombocytopenia. The induction of T cell tolerance is an important mechanism by which the pathogenesis and treatment of immune thrombocytopenia can be studied. Studies regarding the roles of the new inducible costimulator signal transduction pathway, the ubiquitin proteasome pathway, and the nuclear factor kappa B signal transduction pathway in the induction of T cell tolerance can help improve our understanding of immune theory and may provide a new theoretical basis for studying the pathogenesis and treatment of immune thrombocytopenia.

Citing Articles

The function of T cells in immune thrombocytopenia.

Bu S, Liu M, Yang L, Lee P, Miller H, Park C Front Immunol. 2025; 16:1499014.

PMID: 40061938 PMC: 11885273. DOI: 10.3389/fimmu.2025.1499014.

Detection and characterization of autoreactive memory stem T-cells in children with acute immune thrombocytopenia.

Zahran A, El-Badawy O, Mahran H, Gad E, Saad K, Morsy S Clin Exp Med. 2024; 24(1):158.

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The miR-641-STIM1 and SATB1 axes play important roles in the regulation of the Th17/Treg balance in ITP.

Zhu H, Ruan X, Zhao K, Kuang W, Liu S, Yan W Sci Rep. 2024; 14(1):11243.

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Current Understanding of Immune Thrombocytopenia: A Review of Pathogenesis and Treatment Options.

Mititelu A, Onisai M, Rosca A, Vladareanu A Int J Mol Sci. 2024; 25(4).

PMID: 38396839 PMC: 10889445. DOI: 10.3390/ijms25042163.

Knowledge mapping of immune thrombocytopenia: a bibliometric study.

Wu F, Li C, Mao J, Zhu J, Wang Y, Wen C Front Immunol. 2023; 14:1160048.

PMID: 37207211 PMC: 10189105. DOI: 10.3389/fimmu.2023.1160048.

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