Chimeric NP Non Coding Regions Between Type A and C Influenza Viruses Reveal Their Role in Translation Regulation

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Oct 1

PMID 25268971

Citations 1

Authors

Bernadette Crescenzo-Chaigne

Cyril Barbezange

Vianney Frigard

Damien Poulain

Sylvie van der Werf

Affiliations

Soon will be listed here.

Abstract

Exchange of the non coding regions of the NP segment between type A and C influenza viruses was used to demonstrate the importance not only of the proximal panhandle, but also of the initial distal panhandle strength in type specificity. Both elements were found to be compulsory to rescue infectious virus by reverse genetics systems. Interestingly, in type A influenza virus infectious context, the length of the NP segment 5' NC region once transcribed into mRNA was found to impact its translation, and the level of produced NP protein consequently affected the level of viral genome replication.

Citing Articles

Incorporation of the influenza A virus NA segment into virions does not require cognate non-coding sequences.

Crescenzo-Chaigne B, Barbezange C, Leandri S, Roquin C, Berthault C, van der Werf S Sci Rep. 2017; 7:43462.

PMID: 28240311 PMC: 5327478. DOI: 10.1038/srep43462.

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