Brain Metastasis of Crystal-deficient, CD68-positive Alveolar Soft Part Sarcoma: Ultrastructural Features and Differential Diagnosis

Overview

Journal Ultrastruct Pathol

Publisher Informa Healthcare

Date 2014 Oct 1

PMID 25268941

Citations 1

Authors

Matthew D Cykowski

John Hicks

David I Sandberg

Adriana Olar

Julia A Bridge

Patricia T Greipp

Patricia Navarro

Steven Kolodziej

Meenakshi B Bhattacharjee

Affiliations

Soon will be listed here.

Abstract

We report a case of alveolar soft part sarcoma (ASPS) presenting as an isolated frontal lobe metastasis. The tumor demonstrated little or no immunoreactivity for a broad panel of antibodies yet strong, diffuse immunoreactivity with CD68. On electron microscopy, the characteristic rectangular to rhomboid crystalline inclusions of ASPS were not present. Electron-dense granules resembling peroxisomes were present, sometimes in association with elongated granular structures having a periodic, lattice-like arrangement. Metastatic ASPS was confirmed by demonstration of an ASPSCR1-TFE3 fusion and imaging studies that excluded metastatic Xp11.2 translocation renal cell carcinoma. The primary site was subsequently identified in the lower extremity.

Citing Articles

Exploring the Histogenesis and Diagnostic Strategy Using Immunoassay and RT-PCR in Alveolar Soft Part Sarcoma.

Ju X, Sun K, Liu R, Li S, Abulajiang G, Zou H Pathol Oncol Res. 2017; 24(3):593-600.

PMID: 28766250 DOI: 10.1007/s12253-017-0280-9.

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