The Mitochondrial Permeability Transition Pore: Molecular Nature and Role As a Target in Cardioprotection

Overview

Journal J Mol Cell Cardiol

Specialty Cardiology & Vascular Diseases

Date 2014 Oct 1

PMID 25268651

Citations 221

Authors

Paolo Bernardi

Fabio Di Lisa

Affiliations

Soon will be listed here.

Abstract

The mitochondrial permeability transition (PT) - an abrupt increase permeability of the inner membrane to solutes - is a causative event in ischemia-reperfusion injury of the heart, and the focus of intense research in cardioprotection. The PT is due to opening of the PT pore (PTP), a high conductance channel that is critically regulated by a variety of pathophysiological effectors. Very recent work indicates that the PTP forms from the F-ATP synthase, which would switch from an energy-conserving to an energy-dissipating device. This review provides an update on the current debate on how this transition is achieved, and on the PTP as a target for therapeutic intervention. This article is part of a Special Issue entitled "Mitochondria: from basic mitochondrial biology to cardiovascular disease".

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