MHC Class II Association with Lipid Rafts on the Antigen Presenting Cell Surface

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2014 Sep 28

PMID 25261705

Citations 27

Authors

Howard A Anderson

Paul A Roche

Affiliations

Soon will be listed here.

Abstract

MHC class II (MHC-II) molecules function by binding peptides derived from either self or foreign proteins and expressing these peptides on the surface of antigen presenting cells (APCs) for recognition by CD4 T cells. MHC-II is known to exist on clusters on the surface of APCs, and a variety of biochemical and functional studies have suggested that these clusters represent lipid raft microdomain-associated MHC-II. This review will summarize data exploring the biosynthesis of raft-associated MHC-II and the role that lipid raft association plays in regulating T cell activation by APCs. This article is part of a Special Issue entitled: Nanoscale membrane organisation and signalling.

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