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Refractive Index Determination of Nanoparticles in Suspension Using Nanoparticle Tracking Analysis

Overview
Journal Nano Lett
Specialty Biotechnology
Date 2014 Sep 27
PMID 25256919
Citations 63
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Abstract

The refractive index (RI) dictates interaction between light and nanoparticles and therefore is important to health, environmental, and materials sciences. Using nanoparticle tracking analysis, we have determined the RI of heterogeneous particles <500 nm in suspension. We demonstrate feasibility of distinguishing silica and polystyrene beads based on their RI. The hitherto unknown RI of extracellular vesicles from human urine was determined at 1.37 (mean). This method enables differentiation of single nanoparticles based on their RI.

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