Neurodevelopmental Outcome in Congenital Diaphragmatic Hernia: Evaluation, Predictors and Outcome

Overview

Journal World J Clin Pediatr

Publisher Baishideng Publishing Group

Date 2014 Sep 26

PMID 25254182

Citations 12

Authors

Enrico Danzer

Stephen S Kim

Affiliations

Soon will be listed here.

Abstract

To review the reported neurodevelopmental outcome of congenital diaphragmatic hernia (CDH) survivors, identify important predictors of developmental disabilities, and describe the pathophysiological mechanisms contributing to adverse outcome. A Medline search was performed for English-language articles cross-referencing CDH with pertinent search terms. Retrospective, prospective, and longitudinal follow-up studies were examined. The reference lists of identified articles were also searched. Neurodevelopmental dysfunction has been recognized as one of most common and potentially most disabling outcome of CDH. Intelligence appears to be in the low normal to mildly delayed range. Neuromotor dysfunction is common during early childhood. Behavioral problems, hearing impairment, and quality of life related issues are frequently encountered in older children and adolescence. Disease severity correlates with the degree of neurological dysfunction. Neurodevelopmental follow-up in CDH children should become standard of care to identify those who would benefit from early intervention services and improve neurological outcomes.

Citing Articles

Assessment of Physical Performance in Children After Surgery for Congenital Diaphragmatic Hernia.

Palka A, Strumillo B, Piaseczna-Piotrowska A J Clin Med. 2024; 13(23).

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A Rare Pediatric Neurological Case: Dyke-Davidoff-Masson Syndrome Unprecedented at 10 Months.

Khandelwal R, Vagha J, Meshram R, Patel A, K S Cureus. 2024; 16(1):e53168.

PMID: 38420050 PMC: 10901385. DOI: 10.7759/cureus.53168.

The role of point-of-care ultrasound in the management of neonates with congenital diaphragmatic hernia.

Maddaloni C, De Rose D, Ronci S, Pugnaloni F, Martini L, Caoci S Pediatr Res. 2023; 95(4):901-911.

PMID: 37978315 DOI: 10.1038/s41390-023-02889-4.

Brain growth in fetuses with congenital diaphragmatic hernia.

Machado-Rivas F, Choi J, Bedoya M, Acosta Buitrago L, Velasco-Annis C, Afacan O J Neuroimaging. 2023; 33(4):617-624.

PMID: 36813467 PMC: 10363187. DOI: 10.1111/jon.13096.

The Role of Fetal Brain Magnetic Resonance Imaging in Current Fetal Medicine.

Aertsen M J Belg Soc Radiol. 2022; 106(1):130.

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References

Bouman N, Koot H, Tibboel D, Hazebroek F . Children with congenital diaphragmatic hernia are at risk for lower levels of cognitive functioning and increased emotional and behavioral problems. Eur J Pediatr Surg. 2000; 10(1):3-7. DOI: 10.1055/s-2008-1072314. View

Masumoto K, Nagata K, Uesugi T, Yamada T, Taguchi T . Risk factors for sensorineural hearing loss in survivors with severe congenital diaphragmatic hernia. Eur J Pediatr. 2006; 166(6):607-12. DOI: 10.1007/s00431-006-0300-3. View

Nijhuis-van Der Sanden M, van der Cammen-van Zijp M, Janssen A, Reuser J, Mazer P, van Heijst A . Motor performance in five-year-old extracorporeal membrane oxygenation survivors: a population-based study. Crit Care. 2009; 13(2):R47. PMC: 2689491. DOI: 10.1186/cc7770. View

Safavi A, Synnes A, OBrien K, Chiang M, Skarsgard E, Chiu P . Multi-institutional follow-up of patients with congenital diaphragmatic hernia reveals severe disability and variations in practice. J Pediatr Surg. 2012; 47(5):836-41. DOI: 10.1016/j.jpedsurg.2012.01.032. View

Chen C, Jeruss S, Chapman J, Terrin N, Tighiouart H, Glassman E . Long-term functional impact of congenital diaphragmatic hernia repair on children. J Pediatr Surg. 2007; 42(4):657-65. DOI: 10.1016/j.jpedsurg.2006.12.013. View

Tabbutt S, Nord A, Jarvik G, Bernbaum J, Wernovsky G, Gerdes M . Neurodevelopmental outcomes after staged palliation for hypoplastic left heart syndrome. Pediatrics. 2008; 121(3):476-83. DOI: 10.1542/peds.2007-1282. View

Chiu P, Hedrick H . Postnatal management and long-term outcome for survivors with congenital diaphragmatic hernia. Prenat Diagn. 2008; 28(7):592-603. DOI: 10.1002/pd.2007. View

Stolar C, Crisafi M, Driscoll Y . Neurocognitive outcome for neonates treated with extracorporeal membrane oxygenation: are infants with congenital diaphragmatic hernia different?. J Pediatr Surg. 1995; 30(2):366-71; discussion 371-2. DOI: 10.1016/0022-3468(95)90591-x. View

Van Mieghem T, Sandaite I, Michielsen K, Gucciardo L, Done E, Dekoninck P . Fetal cerebral blood flow velocities in congenital diaphragmatic hernia. Ultrasound Obstet Gynecol. 2010; 36(4):452-7. DOI: 10.1002/uog.7703. View

10.

Felderhoff-Mueser U, Ikonomidou C . Mechanisms of neurodegeneration after paediatric brain injury. Curr Opin Neurol. 2000; 13(2):141-5. DOI: 10.1097/00019052-200004000-00005. View

11.

Danzer E, Gerdes M, DAgostino J, Bernbaum J, Siegle J, Hoffman C . Prospective, interdisciplinary follow-up of children with prenatally diagnosed giant omphalocele: short-term neurodevelopmental outcome. J Pediatr Surg. 2010; 45(4):718-23. DOI: 10.1016/j.jpedsurg.2009.09.004. View

12.

Wilson M, Riley P, Hurteau A, Baird R, Puligandla P . Hearing loss in congenital diaphragmatic hernia (CDH) survivors: is it as prevalent as we think?. J Pediatr Surg. 2013; 48(5):942-5. DOI: 10.1016/j.jpedsurg.2013.02.007. View

13.

Volpe J . Brain injury in the premature infant--from pathogenesis to prevention. Brain Dev. 1998; 19(8):519-34. DOI: 10.1016/s0387-7604(97)00078-8. View

14.

Gischler S, Mazer P, Duivenvoorden H, Dijk M, Bax N, Hazebroek F . Interdisciplinary structural follow-up of surgical newborns: a prospective evaluation. J Pediatr Surg. 2009; 44(7):1382-9. DOI: 10.1016/j.jpedsurg.2008.12.034. View

15.

Ten Donkelaar H . Major events in the development of the forebrain. Eur J Morphol. 2001; 38(5):301-8. DOI: 10.1076/ejom.38.5.301.7356. View

16.

van der Cammen-van Zijp M, Gischler S, Mazer P, Dijk M, Tibboel D, IJsselstijn H . Motor-function and exercise capacity in children with major anatomical congenital anomalies: an evaluation at 5 years of age. Early Hum Dev. 2010; 86(8):523-8. DOI: 10.1016/j.earlhumdev.2010.06.014. View

17.

Robertson C, Cheung P, Haluschak M, Elliott C, LEONARD N . High prevalence of sensorineural hearing loss among survivors of neonatal congenital diaphragmatic hernia. Western Canadian ECMO Follow-up Group. Am J Otol. 1998; 19(6):730-6. View

18.

Chen C, Friedman S, Butler S, Jeruss S, Terrin N, Tighiouart H . Approaches to neurodevelopmental assessment in congenital diaphragmatic hernia survivors. J Pediatr Surg. 2007; 42(6):1052-6. DOI: 10.1016/j.jpedsurg.2007.01.042. View

19.

Perlman J . White matter injury in the preterm infant: an important determination of abnormal neurodevelopment outcome. Early Hum Dev. 1999; 53(2):99-120. DOI: 10.1016/s0378-3782(98)00037-1. View

20.

Nobuhara K, Lund D, Mitchell J, Kharasch V, Wilson J . Long-term outlook for survivors of congenital diaphragmatic hernia. Clin Perinatol. 1996; 23(4):873-87. View