Treatment for Superficial Non-ampullary Duodenal Epithelial Tumors

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2014 Sep 26

PMID 25253950

Citations 48

Authors

Naomi Kakushima

Hideyuki Kanemoto

Masaki Tanaka

Kohei Takizawa

Hiroyuki Ono

Affiliations

Soon will be listed here.

Abstract

Because of the low prevalence of non-ampullary duodenal epithelial tumors (NADETs), standardized clinical management of sporadic superficial NADETs, including diagnosis, treatment, and follow-up, has not yet been established. Retrospective studies have revealed certain endoscopic findings suggestive of malignancy. Duodenal adenoma with high-grade dysplasia and mucosal cancer are candidates for local resection by endoscopic or minimally invasive surgery. The use of endoscopic treatment including endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD), for the treatment for superficial NADETs is increasing. EMR requires multiple sessions to achieve complete remission and repetitive endoscopy is needed after resection. ESD provides an excellent complete resection rate, however it remains a challenging method, considering the high risk of intraoperative or delayed perforation. Minimally invasive surgery such as wedge resection and pancreas-sparing duodenectomy are beneficial for superficial NADETs that are technically difficult to remove by endoscopic treatment. Pancreaticoduodenectomy remains a standard surgical procedure for treatment of duodenal cancer with submucosal invasion, which presents a risk of lymph node metastasis. Endoscopic or surgical treatment outcomes of superficial NADETs without submucosal invasion are satisfactory. Establishing an endoscopic diagnostic tool to differentiate superficial NADETs between adenoma and cancer as well as between mucosal and submucosal cancer is required to select the most appropriate treatment.

Citing Articles

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References

Ahmad N, Kochman M, Long W, Furth E, Ginsberg G . Efficacy, safety, and clinical outcomes of endoscopic mucosal resection: a study of 101 cases. Gastrointest Endosc. 2002; 55(3):390-6. DOI: 10.1067/mge.2002.121881. View

Kim H, Chung W, Lee B, Cho Y . Efficacy and long-term outcome of endoscopic treatment of sporadic nonampullary duodenal adenoma. Gut Liver. 2010; 4(3):373-7. PMC: 2956351. DOI: 10.5009/gnl.2010.4.3.373. View

Lang H, Nadalin S, Raab R, Jahne J . [Results of surgical therapy of primary adenocarcinoma of the duodenum]. Chirurg. 1999; 70(5):571-7. DOI: 10.1007/s001040050688. View

Pequin P, Manfredi S, Quentin V, Heresbach D, Boyer J, Siproudhis L . Patients with sporadic duodenal adenoma are a high-risk group for advanced colorectal neoplasia: results of a case-control study. Aliment Pharmacol Ther. 2007; 26(2):277-82. DOI: 10.1111/j.1365-2036.2007.03359.x. View

Negri E, Bosetti C, La Vecchia C, Fioretti F, Conti E, Franceschi S . Risk factors for adenocarcinoma of the small intestine. Int J Cancer. 1999; 82(2):171-4. DOI: 10.1002/(sici)1097-0215(19990719)82:2<171::aid-ijc3>3.0.co;2-t. View

Friedrich-Rust M, Jaeger C, Gossner L, May A, Gunter E, Stolte M . [Early duodenal adenocarcinoma arising in gastric metaplasia treated by endoscopic resection]. Z Gastroenterol. 2006; 44(4):323-8. DOI: 10.1055/s-2006-926492. View

Yamamoto Y, Yoshizawa N, Tomida H, Fujisaki J, Igarashi M . Therapeutic outcomes of endoscopic resection for superficial non-ampullary duodenal tumor. Dig Endosc. 2014; 26 Suppl 2:50-6. DOI: 10.1111/den.12273. View

Witteman B, Janssens A, Griffioen G, Lamers C . Villous tumours of the duodenum. An analysis of the literature with emphasis on malignant transformation. Neth J Med. 1993; 42(1-2):5-11. View

Jepsen J, Persson M, Jakobsen N, Christiansen T, Funch-Jensen P, Kruse A . Prospective study of prevalence and endoscopic and histopathologic characteristics of duodenal polyps in patients submitted to upper endoscopy. Scand J Gastroenterol. 1994; 29(6):483-7. DOI: 10.3109/00365529409092458. View

10.

Spalding D, Isla A, Thompson J, Williamson R . Pancreas-sparing distal duodenectomy for infrapapillary neoplasms. Ann R Coll Surg Engl. 2007; 89(2):130-5. PMC: 1964558. DOI: 10.1308/003588407X155815. View

11.

Konishi M, Kinoshita T, Nakagohri T, Takahashi S, Gotohda N, Ryu M . Pancreas-sparing duodenectomy for duodenal neoplasms including malignancies. Hepatogastroenterology. 2007; 54(75):753-7. View

12.

Matsumoto S, Miyatani H, Yoshida Y . Endoscopic submucosal dissection for duodenal tumors: a single-center experience. Endoscopy. 2012; 45(2):136-7. DOI: 10.1055/s-0032-1310123. View

13.

Ramsoekh D, van Leerdam M, Dekker E, Ouwendijk R, van Dekken H, Kuipers E . Sporadic duodenal adenoma and the association with colorectal neoplasia: a case-control study. Am J Gastroenterol. 2008; 103(6):1505-9. DOI: 10.1111/j.1572-0241.2007.01775.x. View

14.

Scott-Coombes D, Williamson R . Surgical treatment of primary duodenal carcinoma: a personal series. Br J Surg. 1994; 81(10):1472-4. DOI: 10.1002/bjs.1800811023. View

15.

Yoshimura N, Goda K, Tajiri H, Ikegami M, Nakayoshi T, Kaise M . Endoscopic features of nonampullary duodenal tumors with narrow-band imaging. Hepatogastroenterology. 2010; 57(99-100):462-7. View

16.

Cameron J, Riall T, Coleman J, Belcher K . One thousand consecutive pancreaticoduodenectomies. Ann Surg. 2006; 244(1):10-5. PMC: 1570590. DOI: 10.1097/01.sla.0000217673.04165.ea. View

17.

Sakon M, Takata M, Seki H, Hayashi K, Munakata Y, Tateiwa N . A novel combined laparoscopic-endoscopic cooperative approach for duodenal lesions. J Laparoendosc Adv Surg Tech A. 2010; 20(6):555-8. DOI: 10.1089/lap.2009.0392. View

18.

Eisenberger C, Knoefel W, Peiper M, Yekebas E, Hosch S, Busch C . Pancreas-sparing duodenectomy in duodenal pathology: indications and results. Hepatogastroenterology. 2004; 51(57):727-31. View

19.

Sohn T, Lillemoe K, Cameron J, Pitt H, KAUFMAN H, Hruban R . Adenocarcinoma of the duodenum: factors influencing long-term survival. J Gastrointest Surg. 1998; 2(1):79-87. DOI: 10.1016/s1091-255x(98)80107-8. View

20.

Solej M, DAmico S, Brondino G, Ferronato M, Nano M . Primary duodenal adenocarcinoma. Tumori. 2009; 94(6):779-86. DOI: 10.1177/030089160809400601. View