Clinical Impact of Minimal Cancer Cell Detection in Various Colorectal Cancer Specimens

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2014 Sep 26

PMID 25253945

Authors

Kazuhiko Yoshimatsu

Hajime Yokomizo

Yoshihiko Naritaka

Affiliations

Soon will be listed here.

Abstract

Detection of cancer cells using molecular targets is achieved by combining immunochemical reactions with gene amplification techniques. This enables the detection of cancer cells in specimens that are traditionally determined to be cancer-free. These improvements in detection can lead to prognoses that are different from those derived by conventional pathological staging. Survival is worse when cancer cells are detected in regional lymph nodes compared to when the nodes are cancer-free. Furthermore, the circulating tumor cell (CTC) count increases as the cancer progresses. Consequently, there is a correlation between CTC count and prognosis. However, large-scale prospective studies are required to confirm this. The development of more convenient and cost-effective analysis techniques will facilitate the practical application of these findings.

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