Granzyme H Serum Levels Variations with Both Reproductive Hormone Receptors, and Related Hormone Receptors in Breast Cancer Patients

Overview

Journal Iran J Cancer Prev

Specialty Oncology

Date 2014 Sep 25

PMID 25250148

Citations 3

Authors

Behnoosh Tahbaz-Lahafi

Mohammad Esmaeil Akbari

Houshang Amir-Rassouli

Ali Rahimipour

Eznollah Azargashb

Nahid Nafissi

Farida Jahani

Affiliations

Soon will be listed here.

Abstract

Background: Breast Cancer (BC) is the most common cancer in Iranian women, meanwhile the Iranian patients are relatively young. Granzyme H (GZMH) is a functional cytotoxic serine protease of NK cell granules, which expands the cell death-inducing repertoire of innate immune system. GZMH is constitutively and highly expressed in human NK cells, in order to possess chymotrypsin-like (chymase) enzymatic activity. The purpose of this study was to determine GZMH level, in BC and healthy women.

Methods: 30 breast cancer patients, and 30 control women in premenopausal status, have participated in this study. GZMH, Estrogen levels, and ER, PR have been measured in cancer and healthy women subsequently, as using ELISA, Radioimmunoassay, and Immunohistochemistry methods.

Results: Mean GZMH value was lower in BC than healthy women (p<0.0001).

Conclusion: Our study has implicated existence of suppressor or problem for producing of GZMH in patients group and levels of estrogen couldn't effect on making positive ER, PR.

Citing Articles

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Comprehensive Analysis of Prognostic Microenvironment-Related Genes in Invasive Breast Cancer.

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References

Kolahdoozan S, Sadjadi A, Radmard A, Khademi H . Five common cancers in Iran. Arch Iran Med. 2010; 13(2):143-6. View

Akbari A, Razzaghi Z, Homaee F, Khayamzadeh M, Movahedi M, Akbari M . Parity and breastfeeding are preventive measures against breast cancer in Iranian women. Breast Cancer. 2010; 18(1):51-5. DOI: 10.1007/s12282-010-0203-z. View

Fellows E, Gil-Parrado S, Jenne D, Kurschus F . Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program. Blood. 2007; 110(2):544-52. DOI: 10.1182/blood-2006-10-051649. View

Hou Q, Zhao T, Zhang H, Lu H, Zhang Q, Sun L . Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage. Mol Immunol. 2007; 45(4):1044-55. DOI: 10.1016/j.molimm.2007.07.032. View

Clemons M, Goss P . Estrogen and the risk of breast cancer. N Engl J Med. 2001; 344(4):276-85. DOI: 10.1056/NEJM200101253440407. View

Lieberman J . The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. Nat Rev Immunol. 2003; 3(5):361-70. DOI: 10.1038/nri1083. View

Taghavi A, Fazeli Z, Vahedi M, Baghestani A, Pourhoseingholi A, Barzegar F . Increased trend of breast cancer mortality in Iran. Asian Pac J Cancer Prev. 2012; 13(1):367-70. DOI: 10.7314/apjcp.2012.13.1.367. View

Jiang X, Ellison S, Alarid E, Shapiro D . Interplay between the levels of estrogen and estrogen receptor controls the level of the granzyme inhibitor, proteinase inhibitor 9 and susceptibility to immune surveillance by natural killer cells. Oncogene. 2007; 26(28):4106-14. DOI: 10.1038/sj.onc.1210197. View

Razvi N, Khurshid R, Nagra S . To study the significance of apoptotic enzyme granzyme H in breast cancer patients. J Ayub Med Coll Abbottabad. 2008; 20(1):84-6. View

10.

Hashemzadeh S, Aligholipour Maleki R, Ej Golzari S . The incidence of breast cancer in northwest iran (2003 -2008). J Cardiovasc Thorac Res. 2013; 4(1):5-9. PMC: 3825349. DOI: 10.5681/jcvtr.2012.002. View

11.

Roy S, Vadlamudi R . Role of estrogen receptor signaling in breast cancer metastasis. Int J Breast Cancer. 2012; 2012:654698. PMC: 3262597. DOI: 10.1155/2012/654698. View

12.

Gao X, Nawaz Z . Progesterone receptors - animal models and cell signaling in breast cancer: Role of steroid receptor coactivators and corepressors of progesterone receptors in breast cancer. Breast Cancer Res. 2002; 4(5):182-6. PMC: 138741. DOI: 10.1186/bcr449. View

13.

Cullen S, Brunet M, Martin S . Granzymes in cancer and immunity. Cell Death Differ. 2010; 17(4):616-23. DOI: 10.1038/cdd.2009.206. View