The Effects of Calcitriol on Improvement of Insulin Resistance, Ovulation and Comparison with Metformin Therapy in PCOS Patients: a Randomized Placebo- Controlled Clinical Trial

Overview

Journal Iran J Reprod Med

Specialty Reproductive Medicine

Date 2014 Sep 24

PMID 25246913

Citations 19

Authors

Shokoufeh Bonakdaran

Zahra Mazloom Khorasani

Behrooz Davachi

Javad Mazloom Khorasani

Affiliations

Soon will be listed here.

Abstract

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females of reproductive age. Insulin resistance is a frequent metabolic disturbance in PCOS. Vitamin D deficiency is a common problem. Accumulating evidence suggests that vitamin D has a role on insulin sensitivity so may contribute to reduction of hyperandrogenemia.

Objective: The aim was to determine the effects of vitamin D treatment in metabolic components and ovulation evidence in PCOS.

Materials And Methods: Fifty one untreated PCOS patients were randomly divided into three groups and treated with calcitriol, metformin, or placebo. Before and 3 months after treatment, ovulation evidence was assessed by ovarian trans abdominal sonography. Plasma fasting glucose, insulin, homeostasis model assessment insulin resistance (HOMA-IR), 25-hydroxyvitamin D, parathyroid hormone and androgen levels were measured before and after treatment. A 75gr glucose test was performed before and after treatment and two set of results was compared.

Results: Three patients did not continue this study. Only 11 patient (22.9%) had sufficient vitamin D levels (>30 ng/ml). Metformin caused a significant decrease in weight (p=0.027), insulin level (p=0.043), and insulin resistance (p=0.048). Systolic blood pressure and PTH significantly improved after calcitriol (p=0.029, p=0.009 respectively). An improvement in ovulation was detected after calcitriol and seven patients, without evidence of ovulation before treatment, illustrated ovulation after 3 months. Difference with calcitriol in ovulation was significant versus other two methods (p=0.02).

Conclusion: Calcitriol treatment in PCOS may be prior to metformin in ovulation induction.

Citing Articles

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Effects of vitamin D supplementation on ovulation and pregnancy in women with polycystic ovary syndrome: a systematic review and meta-analysis.

Yang M, Shen X, Lu D, Peng J, Zhou S, Xu L Front Endocrinol (Lausanne). 2023; 14:1148556.

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Influence of metformin on hyperandrogenism in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials.

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Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome.

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Kalyanaraman R, Pal L Int J Mol Sci. 2021; 22(9).

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