Comparison of Recombinant Human Follicle Stimulating Hormone (rhFSH), Human Chorionic Gonadotropin (HCG) and Human Menopausal Gonadotropin (HMG) on Semen Parameters After Varicocelectomy: a Randomized Clinical Trial

Overview

Journal Iran J Reprod Med

Specialty Reproductive Medicine

Date 2014 Sep 24

PMID 25246910

Citations 5

Authors

Mohammad Ali Amirzargar

Mahnaz Yavangi

Abbass Basiri

Sayyed Mahdi Hosseini Moghaddam

Hooshang Babbolhavaeji

Nasibeh Amirzargar

Hossein Amirzargar

Leila Moadabshoar

Affiliations

Soon will be listed here.

Abstract

Background: The most frequent physical finding in infertile men is varicocele, in which one of the mechanisms that can affect seminal parameters is oxidative stress.

Objective: Our study aimed, for the first time, to compare the efficacy of recombinant human follicle-stimulating hormone (rhFSH), human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG) on sperm parameters and fertility after varicocelectomy.

Materials And Methods: 113 infertile men with varicocele were divided into four groups. Group A received HCG 5000 IU weekly, group B received HMG 75 IU three times a week, group C received rhFSH 75 IU three times a week and group D received no medical treatment after varicocelectomy.

Results: After three months, in group A sperm morphology improved (p=0.007), causing a 32% pregnancy rate. In group B, sperm motility (p=0.023) and morphology (p=0.014) improved, causing a 57% pregnancy rate. In group C, all of the investigated semen parameters increased (p<0.05), causing a 62.5% pregnancy rate. Only rhFSH improved sperm concentrations to >20×10(6) mL (p=0.027). In group D, sperm morphology increased (p=0.038), but other parameters remained unchanged and no pregnancies occurred.

Conclusion: It can be concluded that drugs can reduce induction time for spermatogenesis and fertility in comparison with varicocelectomy alone. For these purposes, rhFSH is more effective than other drugs.

Citing Articles

Implications of Human Chorionic Gonadotropin (hCG) Therapy in a Varicocele Patient and Its Effect on In Vitro Fertilization (IVF) Outcome.

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Outcome reporting across randomized controlled trials evaluating potential treatments for male infertility: a systematic review.

Rimmer M, Howie R, Subramanian V, Anderson R, Bertolla R, Beebeejaun Y Hum Reprod Open. 2022; 2022(2):hoac010.

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Mutation analysis of TNP1 gene in infertile men with varicocele.

Heidari M, Khatami M, Talebi A, Moezzi F Iran J Reprod Med. 2014; 12(4):257-62.

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The role of flaxseed and vitamin E on oxidative stress in prepubertal rats with experimental varicocele: An experimental study.

Sohrabipour S, Jafari A, Kamalinejad M, Sarrafnejd A, Shahrestany T, Sadeghipour H Iran J Reprod Med. 2014; 11(6):459-66.

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