ABO and Rhesus Blood Groups and Risk of Endometriosis in a French Caucasian Population of 633 Patients Living in the Same Geographic Area

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2014 Sep 23

PMID 25243164

Citations 7

Authors

Bruno Borghese

Melanie Chartier

Carlos Souza

Pietro Santulli

Marie-Christine Lafay-Pillet

Dominique de Ziegler

Charles Chapron

Affiliations

Soon will be listed here.

Abstract

Objectives: The identification of epidemiological factors increasing the risk of endometriosis could shorten the time to diagnosis. Specific blood groups may be more common in patients with endometriosis.

Study Design: We designed a cross-sectional study of 633 Caucasian women living in the same geographic area. Study group included 311 patients with histologically proven endometriosis. Control group included 322 patients without endometriosis as checked during surgery. Frequencies of ABO and Rhesus groups in the study and control groups were compared using univariate and multivariate analyses.

Results: We observed a higher proportion of Rh-negative women in the study group, as compared to healthy controls. Multivariate analysis showed that Rh-negative women are twice as likely to develop endometriosis (aOR = 1.90; 95% CI: 1.20-2.90). There was no significant difference in ABO group distribution between patients and controls. There was no difference when taking into account either the clinical forms (superficial endometriosis, endometrioma, and deep infiltration endometriosis) or the rAFS stages.

Conclusion: Rh-negative women are twice as likely to develop endometriosis. Chromosome 1p, which contains the genes coding for the Rhesus, could also harbor endometriosis susceptibility genes.

Citing Articles

Distribution of ABO and Rh Blood Groups in Patients With Endometriosis at King Abdulaziz University Hospital: A Case-Control Study.

Alhammadi M, Alsaif A, AlGhamdi D, Albasri S Cureus. 2024; 15(12):e51268.

PMID: 38283422 PMC: 10822122. DOI: 10.7759/cureus.51268.

Case-control study to develop and validate a questionnaire for the secondary prevention of endometriosis.

Ricci G, Castelpietra E, Romano F, Lorenzo G, Zito G, Ronfani L PLoS One. 2020; 15(3):e0230828.

PMID: 32226031 PMC: 7105104. DOI: 10.1371/journal.pone.0230828.

Age at menarche does not correlate with the endometriosis phenotype.

Marcellin L, Santulli P, Pinzauti S, Bourdon M, Lamau M, Borghese B PLoS One. 2019; 14(7):e0219497.

PMID: 31335888 PMC: 6650141. DOI: 10.1371/journal.pone.0219497.

Factors associated with deep infiltrating endometriosis versus ovarian endometrioma in China: a subgroup analysis from the FEELING study.

Dai Y, Zhou Y, Zhang X, Xue M, Sun P, Leng J BMC Womens Health. 2018; 18(1):205.

PMID: 30577792 PMC: 6303976. DOI: 10.1186/s12905-018-0697-7.

The Association between ABO and Rh Blood Groups and Risk of Endometriosis in Iranian Women.

Malekzadeh F, Moini A, Amirchaghmaghi E, Daliri L, Akhoond M, Talebi M Int J Fertil Steril. 2018; 12(3):213-217.

PMID: 29935066 PMC: 6018177. DOI: 10.22074/ijfs.2018.5435.

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