No Association of GSTM1 Null Polymorphism with Endometriosis in Women from Central and Southern Iran

Overview

Journal Iran J Reprod Med

Specialty Reproductive Medicine

Date 2014 Sep 23

PMID 25242970

Citations 7

Authors

Seyed Morteza Seifati

Kazem Parivar

Abbas Aflatoonian

Razieh Dehghani Firouzabadi

Mohammad Hasan Sheikhha

Affiliations

Soon will be listed here.

Abstract

Background: Endometriosis is one of the most common gynecologic disorders. It is a complex trait and both genetic and environmental factors have been implicated in its pathogenesis. There is growing evidence indicating that exposure to environmental contaminants is a risk factor for endometriosis. Glutathione-S-Transferase M1 (GSTM1) is one of the genes involved in detoxification of endogenous and exogenous compounds.

Objective: Several studies have indicated an association between GSTM1 null mutation and endometriosis. In this study, the possible association between the GSTM1 gene null genotype and susceptibility to endometriosis in woman from central and southern Iran was investigated.

Materials And Methods: One hundred and one unrelated premenopausal women with endometriosis and 142 unrelated healthy premenopausal women without endometriosis were enrolled in the study. Genomic DNA was extracted from Peripheral blood in all subjects. GSTM1 null genotyping was performed by polymerase chain reaction (PCR).

Results: There was no significant difference between frequencies of GSTM1 null genotype in case and control groups (50.5% Vs. 52.1%, p=0.804). Furthermore, this genotype was not associated with severity of endometriosis in our sample (p=0.77). Conclusion : further studies involving gene-environment and gene-gene interactions, particularly combination of GSTM1 and other GST gene family polymorphisms are needed.

Citing Articles

Defining the genetic profile of endometriosis.

Vassilopoulou L, Matalliotakis M, Zervou M, Matalliotaki C, Krithinakis K, Matalliotakis I Exp Ther Med. 2019; 17(5):3267-3281.

PMID: 30988702 PMC: 6447774. DOI: 10.3892/etm.2019.7346.

Relationship between polymorphism of gene and the risk of endometriosis in an Iranian population: A case-control study.

Babaki A, Mehrjardi E, Firouzabadi R, Aflatoonian A, Seifati S Int J Reprod Biomed. 2019; 16(10):637-640.

PMID: 30643856 PMC: 6314646.

Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian population.

Hassani M, Saliminejad K, Heidarizadeh M, Kamali K, Memariani T, Khorshid H Int J Reprod Biomed. 2016; 14(4):241-6.

PMID: 27351025 PMC: 4918774.

Association between glutathione S-transferase M1/T1 gene polymorphisms and susceptibility to endometriosis: A systematic review and meta-analysis.

Xin X, Jin Z, Gu H, Li Y, Wu T, Hua T Exp Ther Med. 2016; 11(5):1633-1646.

PMID: 27168783 PMC: 4840522. DOI: 10.3892/etm.2016.3110.

Association of TP53 gene codon 72 polymorphism with endometriosis risk in Isfahan.

Dastjerdi M, Aboutorabi R, Eslami Farsani B Iran J Reprod Med. 2014; 11(6):473-8.

PMID: 24639781 PMC: 3941319.

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