Refining the Role for Adult Stem Cells As Cancer Cells of Origin

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2014 Sep 23

PMID 25242116

Citations 70

Authors

Andrew C White

William E Lowry

Affiliations

Soon will be listed here.

Abstract

Significant progress has been made to identify the cells at the foundation of tumorigenesis, the cancer cell of origin (CCO). The majority of data points towards resident adult stem cells (ASCs) or primitive progenitors as the CCO for those cancers studied, highlighting the importance of stem cells not only as propagators but also as initiators of cancer. Recent data suggest tumor initiation at the CCOs can be regulated through both intrinsic and extrinsic signals and that the identity of the CCOs and their propensity to initiate tumorigenesis is context dependent. In this review, we summarize some of the recent findings regarding CCOs and solid tumor initiation and highlight its relation with bona fide human cancer.

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References

Greer J, Whitcomb D . Inflammation and pancreatic cancer: an evidence-based review. Curr Opin Pharmacol. 2009; 9(4):411-8. DOI: 10.1016/j.coph.2009.06.011. View

Kasper M, Jaks V, Are A, Bergstrom A, Schwager A, Svard J . Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes. Proc Natl Acad Sci U S A. 2011; 108(10):4099-104. PMC: 3054016. DOI: 10.1073/pnas.1014489108. View

Lapouge G, Youssef K, Vokaer B, Achouri Y, Michaux C, Sotiropoulou P . Identifying the cellular origin of squamous skin tumors. Proc Natl Acad Sci U S A. 2011; 108(18):7431-6. PMC: 3088632. DOI: 10.1073/pnas.1012720108. View

Moore K, Lemischka I . Stem cells and their niches. Science. 2006; 311(5769):1880-5. DOI: 10.1126/science.1110542. View

Donley N, Thayer M . DNA replication timing, genome stability and cancer: late and/or delayed DNA replication timing is associated with increased genomic instability. Semin Cancer Biol. 2013; 23(2):80-9. PMC: 3615080. DOI: 10.1016/j.semcancer.2013.01.001. View

Sameer A, Chowdri N, Syeed N, Banday M, Shah Z, Siddiqi M . SMAD4--molecular gladiator of the TGF-beta signaling is trampled upon by mutational insufficiency in colorectal carcinoma of Kashmiri population: an analysis with relation to KRAS proto-oncogene. BMC Cancer. 2010; 10:300. PMC: 2927996. DOI: 10.1186/1471-2407-10-300. View

Lapouge G, Beck B, Nassar D, Dubois C, Dekoninck S, Blanpain C . Skin squamous cell carcinoma propagating cells increase with tumour progression and invasiveness. EMBO J. 2012; 31(24):4563-75. PMC: 3545290. DOI: 10.1038/emboj.2012.312. View

Huch M, Dorrell C, Boj S, van Es J, Li V, van de Wetering M . In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature. 2013; 494(7436):247-50. PMC: 3634804. DOI: 10.1038/nature11826. View

Li S, Mao M . Next generation sequencing reveals genetic landscape of hepatocellular carcinomas. Cancer Lett. 2012; 340(2):247-53. DOI: 10.1016/j.canlet.2012.09.027. View

10.

Guasch G, Schober M, Pasolli H, Conn E, Polak L, Fuchs E . Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. Cancer Cell. 2007; 12(4):313-27. PMC: 2424201. DOI: 10.1016/j.ccr.2007.08.020. View

11.

Chen J, Li Y, Yu T, McKay R, Burns D, Kernie S . A restricted cell population propagates glioblastoma growth after chemotherapy. Nature. 2012; 488(7412):522-6. PMC: 3427400. DOI: 10.1038/nature11287. View

12.

Iwai S, Katagiri W, Kong C, Amekawa S, Nakazawa M, Yura Y . Mutations of the APC, beta-catenin, and axin 1 genes and cytoplasmic accumulation of beta-catenin in oral squamous cell carcinoma. J Cancer Res Clin Oncol. 2005; 131(12):773-82. DOI: 10.1007/s00432-005-0027-y. View

13.

Xin L, Lukacs R, Lawson D, Cheng D, Witte O . Self-renewal and multilineage differentiation in vitro from murine prostate stem cells. Stem Cells. 2007; 25(11):2760-9. DOI: 10.1634/stemcells.2007-0355. View

14.

Memarzadeh S, Xin L, Mulholland D, Mansukhani A, Wu H, Teitell M . Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor. Cancer Cell. 2007; 12(6):572-85. PMC: 2931420. DOI: 10.1016/j.ccr.2007.11.002. View

15.

Zong Y, Huang J, Sankarasharma D, Morikawa T, Fukayama M, Epstein J . Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling. Proc Natl Acad Sci U S A. 2012; 109(50):E3395-404. PMC: 3528570. DOI: 10.1073/pnas.1217982109. View

16.

Quigley D, To M, Perez-Losada J, Pelorosso F, Mao J, Nagase H . Genetic architecture of mouse skin inflammation and tumour susceptibility. Nature. 2009; 458(7237):505-8. PMC: 4460995. DOI: 10.1038/nature07683. View

17.

Chenn A, Walsh C . Increased neuronal production, enlarged forebrains and cytoarchitectural distortions in beta-catenin overexpressing transgenic mice. Cereb Cortex. 2003; 13(6):599-606. DOI: 10.1093/cercor/13.6.599. View

18.

Marusyk A, Tabassum D, Altrock P, Almendro V, Michor F, Polyak K . Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity. Nature. 2014; 514(7520):54-8. PMC: 4184961. DOI: 10.1038/nature13556. View

19.

Choi T, Ninov N, Stainier D, Shin D . Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish. Gastroenterology. 2013; 146(3):776-88. PMC: 3943869. DOI: 10.1053/j.gastro.2013.10.019. View

20.

Wang G, Wang J, Mancianti M, Epstein Jr E . Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice. Cancer Cell. 2011; 19(1):114-24. PMC: 3061401. DOI: 10.1016/j.ccr.2010.11.007. View