Epigenetic Inheritance: Histone Bookmarks Across Generations

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2014 Sep 23

PMID 25242115

Citations 72

Authors

Eric I Campos

James M Stafford

Danny Reinberg

Affiliations

Soon will be listed here.

Abstract

Multiple circuitries ensure that cells respond correctly to the environmental cues within defined cellular programs. There is increasing evidence suggesting that cellular memory for these adaptive processes can be passed on through cell divisions and generations. However, the mechanisms by which this epigenetic information is transferred remain elusive, largely because it requires that such memory survive through gross chromatin remodeling events during DNA replication, mitosis, meiosis, and developmental reprogramming. Elucidating the processes by which epigenetic information survives and is transmitted is a central challenge in biology. In this review, we consider recent advances in understanding mechanisms of epigenetic inheritance with a focus on histone segregation at the replication fork, and how an epigenetic memory may get passed through the paternal lineage.

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