Validation of a Magnetic Resonance Imaging Guided Stereotactic Access to the Ovine Brainstem

Overview

Journal BMC Vet Res

Publisher Biomed Central

Specialty Veterinary Medicine

Date 2014 Sep 23

PMID 25241810

Citations 7

Authors

Anne Staudacher

Anna Oevermann

Michael H Stoffel

Daniela Gorgas

Affiliations

Soon will be listed here.

Abstract

Background: Anatomical differences between humans and domestic mammals preclude the use of reported stereotactic approaches to the brainstem in animals. In animals, brainstem biopsies are required both for histopathological diagnosis of neurological disorders and for research purposes. Sheep are used as a translational model for various types of brain disease and therefore a species-specific approach needs to be developed. The aim of the present study was to establish a minimally invasive, accurate and reproducible stereotactic approach to the brainstem of sheep, using the magnetic resonance imaging guided BrainsightTM frameless stereotactic system.

Results: A transoccipital transcerebellar approach with an entry point in the occipital bone above the vermis between the transverse sinus and the external occipital protuberance was chosen. This approach provided access to the target site in all heads. The overall mean needle placement error was 1.85 ± 1.22 mm.

Conclusions: The developed transoccipital transcerebellar route is short, provides accurate access to the ovine caudal cranial fossa and is a promising approach to be further assessed in live animals.

Citing Articles

Mapping sheep to human brain: The need for a sheep brain atlas.

Banstola A, Reynolds J Front Vet Sci. 2022; 9:961413.

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Sampling Method Affects HR-MAS NMR Spectra of Healthy Caprine Brain Biopsies.

Hani A, Diserens G, Oevermann A, Vermathen P, Precht C Metabolites. 2021; 11(1).

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A pilot study of optical neuronavigation-guided brain biopsy in the horse using anatomic landmarks and fiducial arrays for patient registration.

Santistevan L, Easley J, Ruple A, Monck S, Randall E, Wininger F J Vet Intern Med. 2020; 34(4):1642-1649.

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The development of brain magnetic resonance approaches in large animal models for preclinical research.

Ella A, Barriere D, Adriaensen H, Palmer D, Melzer T, Mitchell N Anim Front. 2020; 9(3):44-51.

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Diffusion Tensor Magnetic Resonance Tractography of the Sheep Brain: An Atlas of the Ovine White Matter Fiber Bundles.

Pieri V, Trovatelli M, Cadioli M, Zani D, Brizzola S, Ravasio G Front Vet Sci. 2019; 6:345.

PMID: 31681805 PMC: 6805705. DOI: 10.3389/fvets.2019.00345.

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