Phytochemistry and Biologic Activities of Caulerpa Peltata Native to Oman Sea

Overview

Journal Iran J Pharm Res

Publisher Brieflands

Specialty Pharmacology

Date 2014 Sep 20

PMID 25237346

Citations 9

Authors

Nasrin Movahhedin

Jaleh Barar

Fatemeh Fathi Azad

Abolfazl Barzegari

Hossein Nazemiyeh

Affiliations

Soon will be listed here.

Abstract

General toxicity, antiproliferative, antibacterial and antioxidant activities of Caulerpa peltata J.V.Lamouroux (Caulerpaceae) collected from Oman Sea were investigated. Dried, ground alga was Soxhlet-extracted with hexane, dichloromethane and methanol successively. The methanol extract was subjected to vacuum liquid chromatography (VLC) fractionation on silica gel using a step gradient of different mixture of solvents. A known alkaloid, caulerpin, was subsequently isolated from the fraction eluted by ethyl acatete100%. The antioxidant activity of all extracts was assessed by using the (DPPH) assay. Antiproliferative activity of the all extracts and caulerpin against the cancerous cell line was evaluated using MTT assay. General toxicity of extracts was determined using Brine Shrimp Lethality Assay (BSLA). Based on our results, a weak activity observed for all extracts in MTT assay, while they were toxic toward brine shrimp nauplii comparing to the podophylotoxin. This is the first report on phytochemistry and bioactivity of C. peltata which collected from Oman Sea.

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References

Nazemiyeh H, Bahadori F, Delazar A, Ay M, Topcu G, Nahar L . Antioxidant phenolic compounds from the leaves of Erica Arborea (Ericaceae). Nat Prod Res. 2008; 22(16):1385-92. DOI: 10.1080/14786410701824007. View

da Rocha A, Lopes R, Schwartsmann G . Natural products in anticancer therapy. Curr Opin Pharmacol. 2001; 1(4):364-9. DOI: 10.1016/s1471-4892(01)00063-7. View

Mayer A, Gustafson K . Marine pharmacology in 2003-2004: anti-tumour and cytotoxic compounds. Eur J Cancer. 2006; 42(14):2241-70. DOI: 10.1016/j.ejca.2006.05.019. View

Mayer A, Hamann M . Marine pharmacology in 2001--2002: marine compounds with anthelmintic, antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the.... Comp Biochem Physiol C Toxicol Pharmacol. 2005; 140(3-4):265-86. PMC: 4928201. DOI: 10.1016/j.cca.2005.04.004. View

Mayer A, Gustafson K . Marine pharmacology in 2005-2006: antitumour and cytotoxic compounds. Eur J Cancer. 2008; 44(16):2357-87. PMC: 2629923. DOI: 10.1016/j.ejca.2008.07.001. View

Shoeb M, MacManus S, Kumarasamy Y, Jaspars M, Nahar L, Thoo-Lin P . Americanin, a bioactive dibenzylbutyrolactone lignan, from the seeds of Centaurea americana. Phytochemistry. 2006; 67(21):2370-5. DOI: 10.1016/j.phytochem.2006.08.012. View

Mayer A, Rodriguez A, Berlinck R, Hamann M . Marine pharmacology in 2003-4: marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular,.... Comp Biochem Physiol C Toxicol Pharmacol. 2007; 145(4):553-81. PMC: 2151674. DOI: 10.1016/j.cbpc.2007.01.015. View

Ashour M, Edrada R, Ebel R, Wray V, Watjen W, Padmakumar K . Kahalalide derivatives from the Indian sacoglossan mollusk Elysia grandifolia. J Nat Prod. 2006; 69(11):1547-53. DOI: 10.1021/np060172v. View

Guven K, Percot A, Sezik E . Alkaloids in marine algae. Mar Drugs. 2010; 8(2):269-84. PMC: 2852838. DOI: 10.3390/md8020269. View

10.

Mayer A, Gustafson K . Marine pharmacology in 2001-2: antitumour and cytotoxic compounds. Eur J Cancer. 2004; 40(18):2676-704. DOI: 10.1016/j.ejca.2004.09.005. View

11.

Nazemiyeh H, Rahman M, Gibbons S, Nahar L, Delazar A, Ghahramani M . Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus. J Nat Med. 2008; 62(1):91-5. DOI: 10.1007/s11418-007-0194-z. View

12.

Sarker S, Nahar L, Kumarasamy Y . Microtitre plate-based antibacterial assay incorporating resazurin as an indicator of cell growth, and its application in the in vitro antibacterial screening of phytochemicals. Methods. 2007; 42(4):321-4. PMC: 1895922. DOI: 10.1016/j.ymeth.2007.01.006. View

13.

Hayat S, Atta-Ur-Rahman , Choudhary M, Khan K, Abbaskhan A . Two new cinnamic acid esters from Marine brown alga Spatoglossum variabile. Chem Pharm Bull (Tokyo). 2002; 50(9):1297-9. DOI: 10.1248/cpb.50.1297. View

14.

Schroder H, Badria F, Ayyad S, Batel R, Wiens M, Hassanein H . Inhibitory effects of extracts from the marine alga Caulerpa taxifolia and of toxin from Caulerpa racemosa on multixenobiotic resistance in the marine sponge Geodia cydonium. Environ Toxicol Pharmacol. 2011; 5(2):119-26. DOI: 10.1016/s1382-6689(97)10067-9. View

15.

Mao S, Guo Y, Shen X . Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia. Bioorg Med Chem Lett. 2006; 16(11):2947-50. DOI: 10.1016/j.bmcl.2006.02.074. View

16.

Rocha F, Soares A, Houghton P, Pereira R, Kaplan M, Teixeira V . Potential cytotoxic activity of some Brazilian seaweeds on human melanoma cells. Phytother Res. 2006; 21(2):170-5. DOI: 10.1002/ptr.2038. View