Recovery of Visual Function After Administration of Dabigatran Etexilate

Overview

Journal Case Rep Ophthalmol

Specialty Ophthalmology

Date 2014 Sep 19

PMID 25232340

Authors

Carl-Ludwig Schonfeld

Marie Fischer

Peter Distelmaier

Sebastian Philipp

Patrick Paquet

Katharina Haller

Linda Meyer

Affiliations

Soon will be listed here.

Abstract

A 46-year-old Caucasian female underwent pars plana vitrectomy (ppv) for retinal detachment. After the procedure, the patient could only distinguish hand movements; the condition was tentatively diagnosed as nonarteritic anterior ischemic optic neuropathy. Conventional treatment with systemic corticosteroids and acetylsalicylic acid was ineffective and yielded substantial steroid-related side effects. Additional administration of 2 × 110 mg dabigatran etexilate (Pradaxa(®)), a novel direct thrombin inhibitor, resulted in a prompt and marked improvement of visual acuity, which indicated improved blood flow in the central vessels of the optic nerve. Dabigatran etexilate may provide a promising alternative for the treatment of postprocedural vision loss after ppv.

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