Calreticulin: Roles in Cell-surface Protein Expression

Overview

Journal Membranes (Basel)

Date 2014 Sep 18

PMID 25230046

Citations 18

Authors

Yue Jiang

Sandeepa Dey

Hiroaki Matsunami

Affiliations

Soon will be listed here.

Abstract

In order to perform their designated functions, proteins require precise subcellular localizations. For cell-surface proteins, such as receptors and channels, they are able to transduce signals only when properly targeted to the cell membrane. Calreticulin is a multi-functional chaperone protein involved in protein folding, maturation, and trafficking. However, evidence has been accumulating that calreticulin can also negatively regulate the surface expression of certain receptors and channels. In these instances, depletion of calreticulin enhances cell-surface expression and function. In this review, we discuss the role of calreticulin with a focus on its negative effects on the expression of cell-surface proteins.

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