Interleukin 1 As an Autocrine Growth Factor for Acute Myeloid Leukemia Cells

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1989 Apr 1

PMID 2522658

Citations 26

Authors

F Cozzolino

A Rubartelli

D Aldinucci

R Sitia

M Torcia

A Shaw

R DI GUGLIELMO

Affiliations

Soon will be listed here.

Abstract

Production of interleukin 1 (IL-1) by leukemic cells was studied in 13 cases of acute myeloid leukemia. Intracytoplasmic immunofluorescence studies showed that the cells invariably contained the cytokine. Endogenous labeling studies demonstrated that acute myeloid leukemia cells produced either only the 33-kDa propeptide or both the propeptide and the 17-kDa mature form of IL-1 beta. The 33-kDa propeptide IL-1 alpha was always produced but was less frequently released. Involvement of IL-1 in leukemic cell growth was investigated using two antibodies specific for IL-1 subtypes, which inhibited spontaneous cell proliferation in the six cases studied. After acid treatment of the cells, a surface receptor for IL-1 could be demonstrated, which mediated 125I-labeled IL-1-specific uptake by leukemic cells. Furthermore, recombinant IL-1 alpha or IL-1 beta induced significant cell proliferation in 10 of 12 cases. The above findings were uncorrelated with the cytologic type (French-American-British classification) of leukemia. Our studies suggest that IL-1 may act as an autocrine growth factor in most cases of acute myeloid leukemia.

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References

Laemmli U . Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970; 227(5259):680-5. DOI: 10.1038/227680a0. View

Cozzolino F, Torcia M, MILIANI A, Carossino A, Giordani R, Cinotti S . Potential role of interleukin-1 as the trigger for diffuse intravascular coagulation in acute nonlymphoblastic leukemia. Am J Med. 1988; 84(2):240-50. DOI: 10.1016/0002-9343(88)90420-2. View

Rubartelli A, Sitia R, Zicca A, Grossi C, Ferrarini M . Differentiation of chronic lymphocytic leukemia cells: correlation between the synthesis and secretion of immunoglobulins and the ultrastructure of the malignant cells. Blood. 1983; 62(2):495-504. View

Sporn M, Roberts A . Autocrine growth factors and cancer. Nature. 1985; 313(6005):745-7. DOI: 10.1038/313745a0. View

Schwab R, Crow M, Russo C, Weksler M . Requirements for T cell activation by OKT3 monoclonal antibody: role of modulation of T3 molecules and interleukin 1. J Immunol. 1985; 135(3):1714-8. View

Dower S, Kronheim S, March C, Conlon P, Hopp T, Gillis S . Detection and characterization of high affinity plasma membrane receptors for human interleukin 1. J Exp Med. 1985; 162(2):501-15. PMC: 2187734. DOI: 10.1084/jem.162.2.501. View

Williams J, Deloria D, Hansen J, Dinarello C, Loertscher R, Shapiro H . The events of primary T cell activation can be staged by use of Sepharose-bound anti-T3 (64.1) monoclonal antibody and purified interleukin 1. J Immunol. 1985; 135(4):2249-55. View

Manger B, Weiss A, Weyand C, Goronzy J, Stobo J . T cell activation: differences in the signals required for IL 2 production by nonactivated and activated T cells. J Immunol. 1985; 135(6):3669-73. View

Meuer S, Meyer zum Buschenfelde K . T cell receptor triggering induces responsiveness to interleukin 1 and interleukin 2 but does not lead to T cell proliferation. J Immunol. 1986; 136(11):4106-12. View

10.

Bayne E, Rupp E, Limjuco G, Chin J, Schmidt J . Immunocytochemical detection of interleukin 1 within stimulated human monocytes. J Exp Med. 1986; 163(5):1267-80. PMC: 2188104. DOI: 10.1084/jem.163.5.1267. View

11.

Matsushima K, Akahoshi T, Yamada M, Furutani Y, Oppenheim J . Properties of a specific interleukin 1 (IL 1) receptor on human Epstein Barr virus-transformed B lymphocytes: identity of the receptor for IL 1-alpha and IL 1-beta. J Immunol. 1986; 136(12):4496-502. View

12.

Lowenthal J, MacDonald H . Binding and internalization of interleukin 1 by T cells. Direct evidence for high- and low-affinity classes of interleukin 1 receptor. J Exp Med. 1986; 164(4):1060-74. PMC: 2188417. DOI: 10.1084/jem.164.4.1060. View

13.

Young D, Griffin J . Autocrine secretion of GM-CSF in acute myeloblastic leukemia. Blood. 1986; 68(5):1178-81. View

14.

Wingfield P, Payton M, Tavernier J, Barnes M, Shaw A, Rose K . Purification and characterization of human interleukin-1 beta expressed in recombinant Escherichia coli. Eur J Biochem. 1986; 160(3):491-7. DOI: 10.1111/j.1432-1033.1986.tb10066.x. View

15.

Bird T, Saklatvala J . Identification of a common class of high affinity receptors for both types of porcine interleukin-1 on connective tissue cells. Nature. 1986; 324(6094):263-6. DOI: 10.1038/324263a0. View

16.

Dower S, Kronheim S, Hopp T, Cantrell M, Deeley M, Gillis S . The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical. Nature. 1986; 324(6094):266-8. DOI: 10.1038/324266a0. View

17.

Stoppelli M, Tacchetti C, Cubellis M, Corti A, Hearing V, Cassani G . Autocrine saturation of pro-urokinase receptors on human A431 cells. Cell. 1986; 45(5):675-84. DOI: 10.1016/0092-8674(86)90782-8. View

18.

Young D, Wagner K, Griffin J . Constitutive expression of the granulocyte-macrophage colony-stimulating factor gene in acute myeloblastic leukemia. J Clin Invest. 1987; 79(1):100-6. PMC: 423997. DOI: 10.1172/JCI112769. View

19.

Sieff C, Tsai S, Faller D . Interleukin 1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor. J Clin Invest. 1987; 79(1):48-51. PMC: 423983. DOI: 10.1172/JCI112806. View

20.

Mosley B, Urdal D, Prickett K, Larsen A, Cosman D, Conlon P . The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor. J Biol Chem. 1987; 262(7):2941-4. View