Biotransformation of Huperzine A by a Fungal Endophyte of Huperzia Serrata Furnished Sesquiterpenoid-alkaloid Hybrids

Overview

Journal J Nat Prod

Date 2014 Sep 16

PMID 25222040

Citations 9

Authors

You-Min Ying

Wei-Guang Shan

Zha-Jun Zhan

Affiliations

Soon will be listed here.

Abstract

Biotransformation of huperzine A (hupA) by a fungal endophyte, Ceriporia lacerate HS-ZJUT-C13A, afforded compounds 1-5 and three tremulane sesquiterpenoids, 6-8. Huptremules A-D (1-4) feature unusual sesquiterpenoid-alkaloid hybrid structures that integrate the characteristics of fungal metabolites (tremulane sesquiterpenoids) and the exogenous substrate (hupA). These results support the use of fungal endophytes as biocatalysts for the biotransformation of natural products, particularly those originating from the host plant.

Citing Articles

Multi-Level Optimization and Strategies in Microbial Biotransformation of Nature Products.

Qin D, Dong J Molecules. 2023; 28(6).

PMID: 36985591 PMC: 10051863. DOI: 10.3390/molecules28062619.

Anti-Alzheimer's Natural Products Derived from Plant Endophytic Fungi.

Zhu J, Wang Z, Song L, Fu W, Liu L Molecules. 2023; 28(5).

PMID: 36903506 PMC: 10005758. DOI: 10.3390/molecules28052259.

Whole-Genome Sequencing and Analysis of the White-Rot Fungus Reveals Its Phylogenetic Status and the Genetic Basis of Lignocellulose Degradation and Terpenoid Synthesis.

Mao Z, Yang P, Liu H, Mao Y, Lei Y, Hou D Front Microbiol. 2022; 13:880946.

PMID: 35685935 PMC: 9171200. DOI: 10.3389/fmicb.2022.880946.

New derivatives of the iridoid specioside from fungal biotransformation.

Cassemiro N, Sanches L, Kato N, Ruller R, Carollo C, de Mello J Appl Microbiol Biotechnol. 2021; 105(20):7731-7741.

PMID: 34568964 DOI: 10.1007/s00253-021-11504-7.

Natural Nitrogenous Sesquiterpenoids and Their Bioactivity: A Review.

Chen D, Wang B, Sun Z, Yang J, Xu X, Ma G Molecules. 2020; 25(11).

PMID: 32471218 PMC: 7321145. DOI: 10.3390/molecules25112485.