Middle Cerebral Artery Blood Flows by Combining TCD Velocities and MRA Diameters: in Vitro and in Vivo Validations

Overview

Journal Ultrasound Med Biol

Specialty Radiology

Date 2014 Sep 15

PMID 25218448

Citations 3

Authors

K A Yonan

E R Greene

J M Sharrar

A Caprihan

C Qualls

C A Roldan

Affiliations

Soon will be listed here.

Abstract

Non-invasive transcranial Doppler (TCD) is widely used for blood velocity (BV, cm/sec) measurements in the human middle cerebral artery (MCA). MCABV measurements are accepted as linear with MCA blood flow (MCABF). Magnetic resonance angiography (MRA) provides measurements of MCA lumen diameters that can be combined with TCD MCABV to calculate MCABF (mL/min). We tested the precision and accuracy of this method against a flow phantom and in vivo proximal internal carotid artery blood flow (ICABF). In vitro precision (repeated measures) and accuracy (vs. time collection) gave correlations coefficients of 0.97 and 0.98, respectively (both p < 0.05). In vivo precision (repeated measures) and accuracy (vs. ICABF) gave correlation coefficients of 0.90 (left and right), 0.94 (left) and 0.93 (right) (all p < 0.05). Bilateral MCABF in 35 adults were similar (left, 168 ± 72 mL/min; right, 180 ± 69 mL/min; p > 0.05). Results suggest that blood velocity by TCD and lumen diameter by MRA can be combined to estimate absolute values of MCABF.

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References

Zhang R, Zuckerman J, Giller C, Levine B . Transfer function analysis of dynamic cerebral autoregulation in humans. Am J Physiol. 1998; 274(1 Pt 2):H233-41. DOI: 10.1152/ajpheart.1998.274.1.h233. View

Greene E . Noninvasive transthoracic and transesophageal Doppler echocardiographic measurements of human coronary blood flow velocity: In vitro flow phantom validation. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:3784-7. DOI: 10.1109/IEMBS.2010.5627566. View

Ruggieri P, Laub G, Masaryk T, Modic M . Intracranial circulation: pulse-sequence considerations in three-dimensional (volume) MR angiography. Radiology. 1989; 171(3):785-91. DOI: 10.1148/radiology.171.3.2717753. View

MULLER H, Brunholzl C, Radu E, Buser M . Sex and side differences of cerebral arterial caliber. Neuroradiology. 1991; 33(3):212-6. DOI: 10.1007/BF00588220. View

Martin P, Evans D, Naylor A . Transcranial color-coded sonography of the basal cerebral circulation. Reference data from 115 volunteers. Stroke. 1994; 25(2):390-6. DOI: 10.1161/01.str.25.2.390. View

Wintermark M, Sesay M, Barbier E, Borbely K, Dillon W, Eastwood J . Comparative overview of brain perfusion imaging techniques. Stroke. 2005; 36(9):e83-99. DOI: 10.1161/01.STR.0000177884.72657.8b. View

Lipsitz L, Mukai S, Hamner J, Gagnon M, Babikian V . Dynamic regulation of middle cerebral artery blood flow velocity in aging and hypertension. Stroke. 2000; 31(8):1897-903. DOI: 10.1161/01.str.31.8.1897. View

Hellstrom G, Wahlgren N, Jogestrand T . Carotid artery blood flow and middle cerebral artery blood flow velocity during physical exercise. J Appl Physiol (1985). 1996; 81(1):413-8. DOI: 10.1152/jappl.1996.81.1.413. View

Hatab M, Giller C, Clarke G . Evaluation of cerebral arterial flow with transcranial Doppler ultrasound: theoretical development and phantom studies. Ultrasound Med Biol. 1997; 23(7):1025-31. DOI: 10.1016/s0301-5629(97)00030-6. View

10.

Sorond F, Hollenberg N, Panych L, Fisher N . Brain blood flow and velocity: correlations between magnetic resonance imaging and transcranial Doppler sonography. J Ultrasound Med. 2010; 29(7):1017-22. PMC: 2906813. DOI: 10.7863/jum.2010.29.7.1017. View

11.

Valdueza J, Balzer J, Villringer A, Vogl T, Kutter R, Einhaupl K . Changes in blood flow velocity and diameter of the middle cerebral artery during hyperventilation: assessment with MR and transcranial Doppler sonography. AJNR Am J Neuroradiol. 1997; 18(10):1929-34. PMC: 8337363. View

12.

Moore S, David T, Chase J, Arnold J, Fink J . 3D models of blood flow in the cerebral vasculature. J Biomech. 2005; 39(8):1454-63. DOI: 10.1016/j.jbiomech.2005.04.005. View

13.

Arnolds B, von Reutern G . Transcranial Doppler sonography. Examination technique and normal reference values. Ultrasound Med Biol. 1986; 12(2):115-23. DOI: 10.1016/0301-5629(86)90016-5. View

14.

Panerai R . Transcranial Doppler for evaluation of cerebral autoregulation. Clin Auton Res. 2009; 19(4):197-211. DOI: 10.1007/s10286-009-0011-8. View

15.

Macchi C, Catini C . The measurement of the calibers and blood-flow velocities of the arteries of the circle of Willis: a statistical investigation of 120 living subjects using transcranial color-Doppler ultrasonography. Ital J Anat Embryol. 1994; 99(1):9-16. View

16.

van der Grond J, de Leeuw F, de Groot J, Algra A, Hillen B, Breteler M . Circle of Willis: morphologic variation on three-dimensional time-of-flight MR angiograms. Radiology. 1998; 207(1):103-11. DOI: 10.1148/radiology.207.1.9530305. View

17.

Gonzalez-Alonso J, Dalsgaard M, Osada T, Volianitis S, Dawson E, Yoshiga C . Brain and central haemodynamics and oxygenation during maximal exercise in humans. J Physiol. 2004; 557(Pt 1):331-42. PMC: 1665053. DOI: 10.1113/jphysiol.2004.060574. View

18.

Stock K, Wetzel S, Lyrer P, Radu E . Quantification of blood flow in the middle cerebral artery with phase-contrast MR imaging. Eur Radiol. 2000; 10(11):1795-800. DOI: 10.1007/s003300000378. View

19.

Lin W, Celik A, Derdeyn C, An H, Lee Y, Videen T . Quantitative measurements of cerebral blood flow in patients with unilateral carotid artery occlusion: a PET and MR study. J Magn Reson Imaging. 2001; 14(6):659-67. PMC: 4102701. DOI: 10.1002/jmri.10021. View

20.

Schoning M, Scheel P . Color duplex measurement of cerebral blood flow volume: intra- and interobserver reproducibility and habituation to serial measurements in normal subjects. J Cereb Blood Flow Metab. 1996; 16(3):523-31. DOI: 10.1097/00004647-199605000-00020. View