» Articles » PMID: 25218448

Middle Cerebral Artery Blood Flows by Combining TCD Velocities and MRA Diameters: in Vitro and in Vivo Validations

Overview
Specialty Radiology
Date 2014 Sep 15
PMID 25218448
Citations 3
Authors
Affiliations
Soon will be listed here.
Abstract

Non-invasive transcranial Doppler (TCD) is widely used for blood velocity (BV, cm/sec) measurements in the human middle cerebral artery (MCA). MCABV measurements are accepted as linear with MCA blood flow (MCABF). Magnetic resonance angiography (MRA) provides measurements of MCA lumen diameters that can be combined with TCD MCABV to calculate MCABF (mL/min). We tested the precision and accuracy of this method against a flow phantom and in vivo proximal internal carotid artery blood flow (ICABF). In vitro precision (repeated measures) and accuracy (vs. time collection) gave correlations coefficients of 0.97 and 0.98, respectively (both p < 0.05). In vivo precision (repeated measures) and accuracy (vs. ICABF) gave correlation coefficients of 0.90 (left and right), 0.94 (left) and 0.93 (right) (all p < 0.05). Bilateral MCABF in 35 adults were similar (left, 168 ± 72 mL/min; right, 180 ± 69 mL/min; p > 0.05). Results suggest that blood velocity by TCD and lumen diameter by MRA can be combined to estimate absolute values of MCABF.

Citing Articles

Fast simulation of hemodynamics in intracranial aneurysms for clinical use.

Deuter D, Haj A, Brawanski A, Krenkel L, Schmidt N, Doenitz C Acta Neurochir (Wien). 2025; 167(1):56.

PMID: 40029490 PMC: 11876267. DOI: 10.1007/s00701-025-06469-9.


Validation of bedside manual versus automated measurements of brain arterial diameters from MR angiography.

Garzon-Mancera N, Khasiyev F, Del Brutto V, Spagnolo Allende A, Wright C, Elkind M J Neuroimaging. 2024; 34(5):588-594.

PMID: 38809240 PMC: 11576249. DOI: 10.1111/jon.13217.


Transcranial Doppler-Based Surrogates for Cerebral Blood Flow: A Statistical Study.

Hart J, Novak V, Saunders C, Gremaud P PLoS One. 2016; 11(11):e0165536.

PMID: 27880813 PMC: 5120791. DOI: 10.1371/journal.pone.0165536.


CrossTalk opposing view: The middle cerebral artery diameter does not change during alterations in arterial blood gases and blood pressure.

Brothers R, Zhang R J Physiol. 2016; 594(15):4077-9.

PMID: 27010011 PMC: 4806218. DOI: 10.1113/JP271884.

References
1.
Zhang R, Zuckerman J, Giller C, Levine B . Transfer function analysis of dynamic cerebral autoregulation in humans. Am J Physiol. 1998; 274(1 Pt 2):H233-41. DOI: 10.1152/ajpheart.1998.274.1.h233. View

2.
Greene E . Noninvasive transthoracic and transesophageal Doppler echocardiographic measurements of human coronary blood flow velocity: In vitro flow phantom validation. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:3784-7. DOI: 10.1109/IEMBS.2010.5627566. View

3.
Ruggieri P, Laub G, Masaryk T, Modic M . Intracranial circulation: pulse-sequence considerations in three-dimensional (volume) MR angiography. Radiology. 1989; 171(3):785-91. DOI: 10.1148/radiology.171.3.2717753. View

4.
MULLER H, Brunholzl C, Radu E, Buser M . Sex and side differences of cerebral arterial caliber. Neuroradiology. 1991; 33(3):212-6. DOI: 10.1007/BF00588220. View

5.
Martin P, Evans D, Naylor A . Transcranial color-coded sonography of the basal cerebral circulation. Reference data from 115 volunteers. Stroke. 1994; 25(2):390-6. DOI: 10.1161/01.str.25.2.390. View