» Articles » PMID: 25217556

Suspected Impaired Driving Case Involving α-pyrrolidinovalerophenone, Methylone and Ethylone

Overview
Journal J Anal Toxicol
Specialty Toxicology
Date 2014 Sep 14
PMID 25217556
Citations 11
Authors
Affiliations
Soon will be listed here.
Abstract

This is the first reported case of α-pyrrolidinovalerophenone (α-PVP), methylone and ethylone in a suspected impaired driving case in the state of Washington. An initial traffic stop by law enforcement was made of a driver due to poor navigation of the roadway. The drug recognition expert (DRE) officer observed slurred speech, bloodshot watery eyes, dilated pupils, involuntary muscle movements and an elevated pulse and blood pressure. The DRE deduced that the driver was likely under the influence of central nervous system (CNS) stimulants, specifically 'bath salts'. Routine testing of the blood did not reveal the presence of alcohol or common drugs of abuse. Upon further review of the officer's report and the unconfirmed identification of α-PVP, blood was sent to NMS Labs in Willow Grove, PA, USA for bath salts and stimulant designer drugs testing. Analysis was conducted by liquid chromatography-time-of-flight mass spectrometry with the following results: 63 ng/mL α-PVP, 6.1 ng/mL methylone and positive for ethylone. These results are consistent with the DRE opinion of driving performance being impaired by a CNS stimulant.

Citing Articles

Kratom safety and toxicology in the public health context: research needs to better inform regulation.

Henningfield J, Grundmann O, Huestis M, Smith K Front Pharmacol. 2024; 15:1403140.

PMID: 38887550 PMC: 11180979. DOI: 10.3389/fphar.2024.1403140.


Effects of kratom on driving: Results from a cross-sectional survey, ecological momentary assessment, and pilot simulated driving Study.

Zamarripa C, Spindle T, Panlilio L, Strickland J, Feldman J, Novak M Traffic Inj Prev. 2024; 25(4):594-603.

PMID: 38497810 PMC: 11149710. DOI: 10.1080/15389588.2024.2327827.


Toxicological Analysis of Intoxications with Synthetic Cathinones.

Pieprzyca E, Skowronek R, Czekaj P J Anal Toxicol. 2021; 46(7):705-711.

PMID: 34592764 PMC: 9375235. DOI: 10.1093/jat/bkab102.


An updated review on synthetic cathinones.

Soares J, Costa V, Bastos M, Carvalho F, Capela J Arch Toxicol. 2021; 95(9):2895-2940.

PMID: 34100120 DOI: 10.1007/s00204-021-03083-3.


Pharmacokinetics of α-Pyrrolidinovalerophenone in Male Rats with and without Vaccination with an α-Pyrrolidinovalerophenone Vaccine.

McClenahan S, Gunnell M, Owens M J Pharm Pharm Sci. 2021; 24:267-276.

PMID: 34062113 PMC: 8604100. DOI: 10.18433/jpps31832.