The P53 Control of Apoptosis and Proliferation: Lessons from Drosophila

Overview

Journal Apoptosis

Publisher Springer

Date 2014 Sep 14

PMID 25217223

Citations 35

Authors

Bertrand Mollereau

Dali Ma

Affiliations

Soon will be listed here.

Abstract

The canonical role of p53 in preserving genome integrity and limiting carcinogenesis has been well established. In the presence of acute DNA-damage, oncogene deregulation and other forms of cellular stress, p53 orchestrates a myriad of pleiotropic processes to repair cellular damages and maintain homeostasis. Beside these well-studied functions of p53, recent studies in Drosophila have unraveled intriguing roles of Dmp53 in promoting cell division in apoptosis-induced proliferation, enhancing fitness and proliferation of the winner cell in cell competition and coordinating growth at the organ and organismal level in the presence of stress. In this review, we describe these new functions of Dmp53 and discuss their relevance in the context of carcinogenesis.

Citing Articles

Prospects and Current Challenges of Extracellular Vesicle-Based Biomarkers in Cancer.

Lawrence S, Shah K Biology (Basel). 2024; 13(9).

PMID: 39336121 PMC: 11428408. DOI: 10.3390/biology13090694.

Does the miR-105-1-Kisspeptin Axis Promote Ovarian Cell Functions?.

Fabova Z, Loncova B, Harrath A, Sirotkin A Reprod Sci. 2024; 31(8):2293-2308.

PMID: 38632222 PMC: 11289008. DOI: 10.1007/s43032-024-01554-3.

Understanding the molecular mechanism of regeneration through apoptosis-induced compensatory proliferation studies - updates and future aspects.

Rajagopalan K, Selvan Christyraj J, Subbiahanadar Chelladurai K, Kalimuthu K, Das P, Chandrasekar M Apoptosis. 2024; 29(9-10):1399-1414.

PMID: 38581530 DOI: 10.1007/s10495-024-01958-1.

Bradysia (Sciara) coprophila larvae up-regulate DNA repair pathways and down-regulate developmental regulators in response to ionizing radiation.

Urban J, Bateman J, Garza K, Borden J, Jain J, Brown A Genetics. 2023; 226(3).

PMID: 38066617 PMC: 10917502. DOI: 10.1093/genetics/iyad208.

Differential Effects of Overexpression of Wild Type and Kinase-Dead MELK in Fibroblasts and Keratinocytes, Potential Implications for Skin Wound Healing and Cancer.

Szymanski L, Lieto K, Zdanowski R, Lewicki S, Tassan J, Kubiak J Int J Mol Sci. 2023; 24(9).

PMID: 37175795 PMC: 10179274. DOI: 10.3390/ijms24098089.

References

Miura M . Apoptotic and nonapoptotic caspase functions in animal development. Cold Spring Harb Perspect Biol. 2012; 4(10). PMC: 3475162. DOI: 10.1101/cshperspect.a008664. View

Lefort K, Mandinova A, Ostano P, Kolev V, Calpini V, Kolfschoten I . Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases. Genes Dev. 2007; 21(5):562-77. PMC: 1820898. DOI: 10.1101/gad.1484707. View

Perez-Garijo A, Shlevkov E, Morata G . The role of Dpp and Wg in compensatory proliferation and in the formation of hyperplastic overgrowths caused by apoptotic cells in the Drosophila wing disc. Development. 2009; 136(7):1169-77. DOI: 10.1242/dev.034017. View

Brodsky M, Nordstrom W, Tsang G, Kwan E, Rubin G, Abrams J . Drosophila p53 binds a damage response element at the reaper locus. Cell. 2000; 101(1):103-13. DOI: 10.1016/S0092-8674(00)80627-3. View

Wylie A, Lu W, DBrot A, Buszczak M, Abrams J . p53 activity is selectively licensed in the Drosophila stem cell compartment. Elife. 2014; 3:e01530. PMC: 3949305. DOI: 10.7554/eLife.01530. View

Mendes C, Arama E, Brown S, Scherr H, Srivastava M, Bergmann A . Cytochrome c-d regulates developmental apoptosis in the Drosophila retina. EMBO Rep. 2006; 7(9):933-9. PMC: 1559679. DOI: 10.1038/sj.embor.7400773. View

Valentin-Vega Y, Okano H, Lozano G . The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival. Cell Death Differ. 2008; 15(11):1772-81. PMC: 2742618. DOI: 10.1038/cdd.2008.109. View

Morata G, Shlevkov E, Perez-Garijo A . Mitogenic signaling from apoptotic cells in Drosophila. Dev Growth Differ. 2011; 53(2):168-76. DOI: 10.1111/j.1440-169X.2010.01225.x. View

Mandal S, Guptan P, Owusu-Ansah E, Banerjee U . Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila. Dev Cell. 2005; 9(6):843-54. DOI: 10.1016/j.devcel.2005.11.006. View

10.

Maiuri M, Galluzzi L, Morselli E, Kepp O, Malik S, Kroemer G . Autophagy regulation by p53. Curr Opin Cell Biol. 2010; 22(2):181-5. DOI: 10.1016/j.ceb.2009.12.001. View

11.

Fan Y, Bergmann A . Apoptosis-induced compensatory proliferation. The Cell is dead. Long live the Cell!. Trends Cell Biol. 2008; 18(10):467-73. PMC: 2705980. DOI: 10.1016/j.tcb.2008.08.001. View

12.

Rutkowski R, Hofmann K, Gartner A . Phylogeny and function of the invertebrate p53 superfamily. Cold Spring Harb Perspect Biol. 2010; 2(7):a001131. PMC: 2890203. DOI: 10.1101/cshperspect.a001131. View

13.

Brodsky M, Weinert B, Tsang G, Rong Y, McGinnis N, Golic K . Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. Mol Cell Biol. 2004; 24(3):1219-31. PMC: 321428. DOI: 10.1128/MCB.24.3.1219-1231.2004. View

14.

White K, Grether M, Abrams J, Young L, Farrell K, Steller H . Genetic control of programmed cell death in Drosophila. Science. 1994; 264(5159):677-83. DOI: 10.1126/science.8171319. View

15.

Huang Q, Li F, Liu X, Li W, Shi W, Liu F . Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nat Med. 2011; 17(7):860-6. PMC: 3132290. DOI: 10.1038/nm.2385. View

16.

Wells B, Yoshida E, Johnston L . Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity. Curr Biol. 2006; 16(16):1606-15. PMC: 1764442. DOI: 10.1016/j.cub.2006.07.046. View

17.

de la Cova C, Senoo-Matsuda N, Ziosi M, Wu D, Bellosta P, Quinzii C . Supercompetitor status of Drosophila Myc cells requires p53 as a fitness sensor to reprogram metabolism and promote viability. Cell Metab. 2014; 19(3):470-83. PMC: 3970267. DOI: 10.1016/j.cmet.2014.01.012. View

18.

Fan Y, Lee T, Xu D, Chen Z, Lamblin A, Steller H . Dual roles of Drosophila p53 in cell death and cell differentiation. Cell Death Differ. 2009; 17(6):912-21. PMC: 3014827. DOI: 10.1038/cdd.2009.182. View

19.

Brady C, Attardi L . p53 at a glance. J Cell Sci. 2010; 123(Pt 15):2527-32. PMC: 2912460. DOI: 10.1242/jcs.064501. View

20.

Moreno E, Basler K . dMyc transforms cells into super-competitors. Cell. 2004; 117(1):117-29. DOI: 10.1016/s0092-8674(04)00262-4. View