Animal Models of HIV Peripheral Neuropathy

Overview

Journal Future Virol

Specialty Microbiology

Date 2014 Sep 13

PMID 25214880

Citations 10

Authors

Tricia H Burdo

Andrew D Miller

Affiliations

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Abstract

The use of animal models in the study of HIV and AIDS has advanced our understanding of the underlying pathophysiologic mechanisms of infection. Of the multitude of HIV disease manifestations, peripheral neuropathy remains one of the most common long-term side effects. Several of the most important causes of peripheral neuropathy in AIDS patients include direct association with HIV infection with or without antiretroviral medication and infection with opportunistic agents. Because the pathogeneses of these diseases are difficult to study in human patients, animal models have allowed for significant advancement in the understanding of the role of viral infection and the immune system in disease genesis. This review focuses on rodent, rabbit, feline and rhesus models used to study HIV-associated peripheral neuropathies, focusing specifically on sensory neuropathy and antiretroviral-associated neuropathies.

Citing Articles

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Neuroinflammation in the Dorsal Root Ganglia and Dorsal Horn Contributes to Persistence of Nociceptor Sensitization in SIV-Infected Antiretroviral Therapy-Treated Macaques.

Warfield R, Robinson J, Podgorski R, Miller A, Burdo T Am J Pathol. 2023; 193(12):2017-2030.

PMID: 37734588 PMC: 10699130. DOI: 10.1016/j.ajpath.2023.08.014.

Critical Pronociceptive Role of Family 2 Voltage-Gated Calcium Channels in a Novel Mouse Model of HIV-Associated Sensory Neuropathy.

Luckemeyer D, Prudente A, de Amorim Ferreira M, da Silva A, Tonello R, Macedo Junior S Mol Neurobiol. 2023; 60(5):2954-2968.

PMID: 36754911 DOI: 10.1007/s12035-023-03244-8.

HIV-1 and drug abuse comorbidity: Lessons learned from the animal models of NeuroHIV.

Sil S, Thangaraj A, Chivero E, Niu F, Kannan M, Liao K Neurosci Lett. 2021; 754:135863.

PMID: 33794296 PMC: 8108725. DOI: 10.1016/j.neulet.2021.135863.

Atrophy and Death of Nonpeptidergic and Peptidergic Nociceptive Neurons in SIV Infection.

Robinson J, Guenthner G, Warfield R, Kublin J, Smith M, Shekarabi M Am J Pathol. 2020; 190(7):1530-1544.

PMID: 32246920 PMC: 7322364. DOI: 10.1016/j.ajpath.2020.03.004.

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