Oral Fluid Based Biomarkers in Periodontal Disease: Part 1. Saliva

Overview

Journal J Int Oral Health

Date 2014 Sep 13

PMID 25214743

Citations 17

Authors

Hani S AlMoharib

Abdulrahman AlMubarak

Raed AlRowis

Amrita Geevarghese

R S Preethanath

Sukumaran Anil

Affiliations

Soon will be listed here.

Abstract

Traditional clinical measurements such as probing pocket depth, bleeding on probing, clinical attachment loss; plaque index and radiographs used for periodontal diagnosis are often of limited usefulness as they are indicators of previous periodontal disease rather than present disease activity. A literature search was carried out to find out all the available tests that indicate periodontal disease markers in saliva. All major databases were searched to compile the information on published reports between 1999 and 2014. The list of biomarkers available to date is compiled and presented in a table format. Each biomarker is discussed separately based on the available evidence. Based on the evidence, it can be concluded that several sensitive salivary indicators of periodontitis are available to detect the presence, severity and response to treatment. Further studies are warranted to analyze the sensitivity and reliability of these indicators that might help in developing non-invasive tests that could help in the diagnosis of periodontal disease.

Citing Articles

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The Association Between Periodontal Inflamed Surface Area (PISA), Inflammatory Biomarkers, and Mitochondrial DNA Copy Number.

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Salivary microbiota dysbiosis and elevated polyamine levels contribute to the severity of periodontal disease.

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Progress in salivary glands: Endocrine glands with immune functions.

Shang Y, Shen Y, Zhang M, Lv M, Wang T, Chen X Front Endocrinol (Lausanne). 2023; 14:1061235.

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Evaluation of cannabinoid receptors type 1-2 in periodontitis patients.

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