Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:

Overview

Journal Balkan Med J

Publisher Galenos Publishing House

Specialty General Medicine

Date 2014 Sep 11

PMID 25207142

Citations 2

Authors

Ahmet Rahmi Hatipoglu

Serhat Oguz

Saban Gurcan

Tulin Yalta

Dogan Albayrak

Cengiz Erenoglu

Tamer Sagiroglu

Yavuz Atakan Sezer

Affiliations

Soon will be listed here.

Abstract

Background: Bacterial Translocation is believed to be an important factor on mortality and morbidity in Obstructive Jaundiced.

Aims: We investigated the probable or estimated positive effects of tauroursodeoxycholic acid, which has antibacterial and regulatory effects on intestinal flora, together with glutamine on BT in an experimental obstructive jaundiced rat model.

Study Design: Animal experimentation.

Methods: Forty adult, male, Sprague Dawley rats were used in this study. Animals were randomised and divided into five groups of eight each: sham (Sh); control (common bile duct ligation, CBDL); and supplementation groups administered tauroursodeoxycholic acid (CBDL+T), glutamine (CBDL+G), or tauroursodeoxycholic acid plus glutamine (CBDL+TG). Blood and liver, spleen, MLN, and ileal samples were taken via laparotomy under sterile conditions for investigation of bacterial translocation and intestinal mucosal integrity and hepatic function tests on the tenth postoperative day.

Results: There were statistically significant differences in BT rates in all samples except the spleen of the CBDL+TG group compared with the CBDL group (p=0.041, p=0.026, and p=0.041, respectively).

Conclusion: It is essential to protect hepatic functions besides maintaining intestinal mucosal integrity in the active struggle against BT occurring in obstructive jaundice. The positive effect on intestinal mucosal integrity can be increased if glutamine is used with tauroursodeoxycholic acid, which also has hepatoprotective and immunomodulatory features.

Citing Articles

Modulation of the Unfolded Protein Response by Tauroursodeoxycholic Acid Counteracts Apoptotic Cell Death and Fibrosis in a Mouse Model for Secondary Biliary Liver Fibrosis.

Paridaens A, Raevens S, Devisscher L, Bogaerts E, Verhelst X, Hoorens A Int J Mol Sci. 2017; 18(1).

PMID: 28117681 PMC: 5297843. DOI: 10.3390/ijms18010214.

L-carnitine reduces acute lung injury in experimental biliary obstruction.

Kaya O, Koca Y, Barut I, Baspinar S, Sabuncuoglu M Saudi Med J. 2015; 36(9):1046-52.

PMID: 26318460 PMC: 4613627. DOI: 10.15537/smj.2015.9.12206.

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