Mechanical Tension Promotes Skin Nerve Regeneration by Upregulating Nerve Growth Factor Expression

Overview

Journal Neural Regen Res

Date 2014 Sep 11

PMID 25206453

Citations 2

Authors

Hu Xiao

Dechang Wang

Ran Huo

Yibing Wang

Yongqiang Feng

Qiang Li

Affiliations

Soon will be listed here.

Abstract

This study aimed to explore the role of mechanical tension in hypertrophic scars and the change in nerve density using hematoxylin-eosin staining and S100 immunohistochemistry, and to observe the expression of nerve growth factor by western blot analysis. The results demonstrated that mechanical tension contributed to the formation of a hyperplastic scar in the back skin of rats, in conjunction with increases in both nerve density and nerve growth factor expression in the scar tissue. These experimental findings indicate that the cutaneous nervous system plays a role in hypertrophic scar formation caused by mechanical tension.

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