The Multifunctional and Multi-system Influence of Ghrelin in the Treatment of Diabetic and Spinal Cord Injury Induced Neuropathy

Overview

Journal Ann Neurosci

Publisher Sage Publications

Specialty Neurology

Date 2014 Sep 11

PMID 25205937

Citations 4

Authors

Dp Fields

Ss Miranpuri

Gs Miranpuri

Dk Resnick

Affiliations

Soon will be listed here.

Abstract

Ghrelin (Gh), a small peptide, which was originally discovered as a gastrointestinal (GI) tropic hormone, has shown to have a presence and function within multiple tissue systems. Recently, Gh has shown to exhibit anti-inflammatory and regenerative abilities in response to both chemical and mechanical stressors within neural tissues. By continuing to elucidate the potential applications of Gh on pathological neural states, the viability of this peptide hormone for therapeutic uses can be explored for future clinical application.

Citing Articles

The Burden of Peripheral Neuropathy in Nondiabetic Chronic Kidney Disease and the Role of Ghrelin Isoforms in its Development.

Ramachandran M, Subramanian V, Kuppusamy S, Parameswaran S, Chinnakali P, Vairappan B Indian J Nephrol. 2023; 32(6):567-573.

PMID: 36704594 PMC: 9872928. DOI: 10.4103/ijn.IJN_557_20.

Effect of unacylated ghrelin on peripheral nerve regeneration.

Ronchi G, Tos P, Angelino E, Muratori L, Reano S, Filigheddu N Eur J Histochem. 2021; 65(s1).

PMID: 34734521 PMC: 8586818. DOI: 10.4081/ejh.2021.3287.

Ghrelin-Mediated Regeneration and Plasticity After Nervous System Injury.

Stoyanova I, Lutz D Front Cell Dev Biol. 2021; 9:595914.

PMID: 33869167 PMC: 8046019. DOI: 10.3389/fcell.2021.595914.

GH deficiency in patients with spinal cord injury: efficacy/safety of GH replacement, a pilot study.

Cuatrecasas G, Kumru H, Coves M, Vidal J Endocr Connect. 2018; 7(10):1031-1039.

PMID: 30352393 PMC: 6198193. DOI: 10.1530/EC-18-0296.

References

Lee J, Chung H, Yoo Y, Oh Y, Oh T, Park S . Inhibition of apoptotic cell death by ghrelin improves functional recovery after spinal cord injury. Endocrinology. 2010; 151(8):3815-26. DOI: 10.1210/en.2009-1416. View

Pitcher M, Cervero F . Role of the NKCC1 co-transporter in sensitization of spinal nociceptive neurons. Pain. 2010; 151(3):756-762. DOI: 10.1016/j.pain.2010.09.008. View

Bar Ad V . Gabapentin for the treatment of cancer-related pain syndromes. Rev Recent Clin Trials. 2010; 5(3):174-8. DOI: 10.2174/157488710792007310. View

Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K . Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999; 402(6762):656-60. DOI: 10.1038/45230. View

Melli G, Hoke A . Dorsal Root Ganglia Sensory Neuronal Cultures: a tool for drug discovery for peripheral neuropathies. Expert Opin Drug Discov. 2010; 4(10):1035-1045. PMC: 2908326. DOI: 10.1517/17460440903266829. View

Tahrani A, Askwith T, Stevens M . Emerging drugs for diabetic neuropathy. Expert Opin Emerg Drugs. 2010; 15(4):661-83. DOI: 10.1517/14728214.2010.512610. View

Fear C . Neuropathic pain: clinical features, assessment and treatment. Nurs Stand. 2010; 25(6):35-40. DOI: 10.7748/ns2010.10.25.6.35.c8037. View

Hasbargen T, Ahmed M, Miranpuri G, Li L, Kahle K, Resnick D . Role of NKCC1 and KCC2 in the development of chronic neuropathic pain following spinal cord injury. Ann N Y Acad Sci. 2010; 1198:168-72. DOI: 10.1111/j.1749-6632.2010.05462.x. View

King G . The role of inflammatory cytokines in diabetes and its complications. J Periodontol. 2008; 79(8 Suppl):1527-34. DOI: 10.1902/jop.2008.080246. View

10.

Vergnano A, Ferrini F, Salio C, Lossi L, Baratta M, Merighi A . The gastrointestinal hormone ghrelin modulates inhibitory neurotransmission in deep laminae of mouse spinal cord dorsal horn. Endocrinology. 2008; 149(5):2306-12. DOI: 10.1210/en.2007-1164. View

11.

Wallace M, Irving G, Cowles V . Gabapentin extended-release tablets for the treatment of patients with postherpetic neuralgia: a randomized, double-blind, placebo-controlled, multicentre study. Clin Drug Investig. 2010; 30(11):765-76. DOI: 10.2165/11539520-000000000-00000. View

12.

Inoue Y, Nakahara K, Kangawa K, Murakami N . Transitional change in rat fetal cell proliferation in response to ghrelin and des-acyl ghrelin during the last stage of pregnancy. Biochem Biophys Res Commun. 2010; 393(3):455-60. DOI: 10.1016/j.bbrc.2010.02.022. View

13.

Ossipov M, Porreca F . Challenges in the development of novel treatment strategies for neuropathic pain. NeuroRx. 2006; 2(4):650-61. PMC: 1201322. DOI: 10.1602/neurorx.2.4.650. View

14.

Moore K, Kohno T, Karchewski L, Scholz J, Baba H, Woolf C . Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord. J Neurosci. 2002; 22(15):6724-31. PMC: 6758148. DOI: 20026611. View

15.

Talbot S, Chahmi E, Dias J, Couture R . Key role for spinal dorsal horn microglial kinin B1 receptor in early diabetic pain neuropathy. J Neuroinflammation. 2010; 7(1):36. PMC: 2913947. DOI: 10.1186/1742-2094-7-36. View

16.

Bulgarelli I, Tamiazzo L, Bresciani E, Rapetti D, Caporali S, Lattuada D . Desacyl-ghrelin and synthetic GH-secretagogues modulate the production of inflammatory cytokines in mouse microglia cells stimulated by beta-amyloid fibrils. J Neurosci Res. 2009; 87(12):2718-27. DOI: 10.1002/jnr.22088. View

17.

Petit Jr W, Upender R . Medical evaluation and treatment of diabetic peripheral neuropathy. Clin Podiatr Med Surg. 2003; 20(4):671-88. DOI: 10.1016/S0891-8422(03)00068-5. View

18.

Schwartzman R, Maleki J . Postinjury neuropathic pain syndromes. Med Clin North Am. 1999; 83(3):597-626. DOI: 10.1016/s0025-7125(05)70126-7. View

19.

Greene D, Stevens M, Obrosova I, Feldman E . Glucose-induced oxidative stress and programmed cell death in diabetic neuropathy. Eur J Pharmacol. 1999; 375(1-3):217-23. DOI: 10.1016/s0014-2999(99)00356-8. View

20.

Guneli E, Kazikdas K, Kolatan E . Ghrelin may attenuate proinflammatory cytokine-mediated neuropathic pain. Med Hypotheses. 2007; 69(2):356-60. DOI: 10.1016/j.mehy.2006.12.042. View